Myeloid-related protein (MRP14), or calcium-protecting protein (S100-A9), is a member of the S100 family proteins containing two EF-hand calcium-binding motifs (1). S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and they are involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation (2). S100-A9 forms a heterodimer, calprotectin, with S100-A8 in a calcium-dependent manner (3). Calprotectin is a major calcium- and zinc-binding protein in the cytosol of neutrophils, monocytes, and keratinocytes (4). S100-A9 may function in the inhibition of casein kinase, and altered expression of this protein is associated with the disease cystic fibrosis (2).
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