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Anti-TIMP1 Antibody EPR1550
* Buy one primary antibody, get 50% off a GAPDH loading control antibody.
Also for TIMP1 (NM_003254)
|A synthetic peptide corresponding to residues in human TIMP-1 was used as an immunogen.|
||IHC: 1:250 - 500, WB: 1:1,000 - 10,000,
|Store at -20C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.|
|Homo sapiens TIMP metallopeptidase inhibitor 1 (TIMP1)|
|CLGI; EPA; EPO; HCI; TIMP|
|Tissue inhibitor of metalloproteinase 1 (TIMP-1) is a stromal factor which forms complexes with various members of matrix metalloproteinases (MMPs) and irreversibly inactivates them. A multifunctional glycoprotein, TIMP-1 is one of the four members of TIMP family (TIMP 1-4) which exhibits 50% sequence similarity and expressed in wide variety of cells (1). TIMP-1 binds non-covalently in a 1:1 stoichiometric fashion to the active form of MMPs thereby inhibiting the proteolytic activity of these enzymes. In addition to inhibitory function, other studies have proposed growth protion, anti-apoptotic, anti- and pro-angiogenic functions for TIMP-1. TIMP-1 expression has been observed in poor clinical outcome in many cancer types, making it ideal prognostic marker in various cancer (2).|
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Western blot analysis on (A) HL-60+TPA and (B) PBMC lysates using anti-TIMP-1 RabMAb .
Immunohistochemical analysis of paraffin-embedded human liver tissue using anti-TIMP-1 RabMAb .