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Anti-TIMP1 Antibody EPR1550


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SKU Description Amount Price Availability*  
  • Rabbit monoclonal antibody against TIMP-1(clone EPR1550)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC418808) , 20ug Explanation
100ul $325 3-7 Days
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OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human TIMP-1 was used as an immunogen.
Clone NameEPR1550 IsotypeIgG
Species ReactivityHuman (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1:1000 - 1:10000; IHC-P: 1:250 - 1:500
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Note Is unsuitable for Flow Cyt,ICC or IP.

Reference Data

Target NameHomo sapiens TIMP metallopeptidase inhibitor 1 (TIMP1)
Alternative NameCLGI; EPA; EPO; HCI; TIMP
Database LinkNP_003245
Entrez Gene 7076 Human
FunctionTissue inhibitor of metalloproteinase 1 (TIMP-1) is a stromal factor which forms complexes with various members of matrix metalloproteinases (MMPs) and irreversibly inactivates them. A multifunctional glycoprotein, TIMP-1 is one of the four members of TIMP family (TIMP 1-4) which exhibits 50% sequence similarity and expressed in wide variety of cells (1). TIMP-1 binds non-covalently in a 1:1 stoichiometric fashion to the active form of MMPs thereby inhibiting the proteolytic activity of these enzymes. In addition to inhibitory function, other studies have proposed growth protion, anti-apoptotic, anti- and pro-angiogenic functions for TIMP-1. TIMP-1 expression has been observed in poor clinical outcome in many cancer types, making it ideal prognostic marker in various cancer (2).
Related PathwaySecreted ProteinDruggable Genome

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Western blot - TIMP1 antibody [EPR1550]; All lanes : Anti-TIMP1 antibody [EPR1550] at 1/1000 dilution.Lane 1 : HL60+TPA cell lysates.Lane 2 : PBMC cell lysates.Lysates/proteins at 10 ug per lane.Predicted band size : 23 kDa.
Western blot - TIMP1 antibody [EPR1550]; Anti-TIMP1 antibody [EPR1550] at 1/1000 dilution + TIMP1 recombinant protein at 10 ug.Predicted band size : 23 kDa.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - TIMP1 antibody [EPR1550]; TA307371, at 1/250 dilution staining TIMP1 in paraffin-embedded Human liver tissue, by Immunohistochemistry.


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