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Anti-TRADD Antibody EPR3604

* Buy one primary antibody, get 50% off a GAPDH loading control antibody.

WB(1)

IHC(1)

IF(1)

OriGene Data

Immunogen	A synthetic peptide corresponding to residues in human TRADD was used as an immunogen.
Clone Name	EPR3604	Isotype	Rabbit IgG
Species Reactivity	Human, Mouse, Rat	Concentration
Guaranteed Application *	WB, IHC, IF	Suggested Dilutions	ICC: 1:100, IHC: 1:100, IP: 1:10, WB: 1:500 - 1,000,
Buffer	Store at -20 C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
Purification	(Protein A or G Sepharose)

Reference Data

Target Name	Homo sapiens TNFRSF1A-associated via death domain (TRADD)
Alternative Name	Hs.89862
Database Link	NP_003780
Function	TRADD (TNF-R1 associated death domain) is a multifunctional signaling adaptor protein that is essential in recruiting signaling molecules to the TNFR1 receptor complex (1, 3). It mediates TNFR1 activation of NF-kappaB and c-Jun N-terminal kinase (JNK), as well as caspase-dependent apoptosis (2). The C-terminal of TRADD comprises the "death domain" that is responsible for association of TNFR1 and other death domain-containing proteins such as FADD and RIP. The N-terminal domain promotes the recruitment of TRAF2 to TNFR1, leading to the activation of JNK/AP1 and NF-kappa B (1). TRADD is suggested to also be involved in IFN-gamma signaling by forming a complex with STAT1-alpha within the nucleus and regulating IFN-gamma-mediated STAT1-alpha activation (3).
Related Pathway	Apoptosis

Related Lysate from OriGene • Transient overexpression lysate of TNFRSF1A-associated via death domain (TRADD) Anti-Tag Antibodies & WB Reagent • Anti-Tag Antibodies • Western Blot Reagent shRNA • TRADD - Human, 4 unique 29mer shRNA constructs in retroviral RFP vector • TRADD - Human, 4 unique 29mer shRNA constructs in retroviral GFP vector • Tradd - Mouse, 4 unique 29mer shRNA constructs in retroviral GFP vector • TRADD - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector • Tradd - Mouse, 4 unique 29mer shRNA constructs in retroviral untagged vector Related ORF Clones • Myc-DDK-tagged ORF clone of Homo sapiens TNFRSF1A-associated via death domain (TRADD) as transfection-ready DNA • GFP-tagged ORF clone of Homo sapiens TNFRSF1A-associated via death domain (TRADD) as transfection-ready DNA • Lenti ORF clone of Human TNFRSF1A-associated via death domain (TRADD) , Myc-DDK-tagged • Lenti ORF clone of Human TNFRSF1A-associated via death domain (TRADD), mGFP tagged Related cDNA Clones • Homo sapiens TNFRSF1A-associated via death domain (TRADD) as transfection-ready DNA

Conjugation Services
OriGene provides conjugation services of TrueMAB antibodies with the following molecules:

• HRP
• Biotin
• PE
• FITC
• DyLight® 488
• DyLight® 550
• DyLight® 594
• DyLight® 633

* DyLight is a trademark of Thermo-Fisher Scientific

Bulk Order
OriGene offers bulk sizes of TrueMAB antibodies in both the BSA/glycerol formulation and the carrier-free (BSA/glycerol-free) formulation.

Contact us with your conjugation/bulk request: antibody@origene.com or 888-267-4436 (Tech Support)