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Anti-TRADD Antibody EPR3604


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SKU Description Amount Price Availability*  
  • Rabbit monoclonal antibody against TRADD(clone EPR3604)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC401247) , 20ug Explanation
100ul $325 3 Weeks

Buy any antibody of 100ul or more, get a free package of 3 loading control antibody samples. View Details Add to Shopping Cart


OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human TRADD was used as an immunogen.
Clone NameEPR3604 IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC, IF Suggested DilutionsWB: 1:500 - 1:1000; IP: 1:10; IHC-P: 1:100; ICC: 1:100
Predicted MW Explanation 34 kDa
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Is unsuitable for Flow Cyt.

Reference Data

Target NameHomo sapiens TNFRSF1A-associated via death domain (TRADD)
Alternative NameHs.89862
Database LinkNP_003780
Entrez Gene 8717 Human
Entrez Gene 71609 Mouse
Entrez Gene 246756 Rat
FunctionTRADD (TNF-R1 associated death domain) is a multifunctional signaling adaptor protein that is essential in recruiting signaling molecules to the TNFR1 receptor complex (1, 3). It mediates TNFR1 activation of NF-kappaB and c-Jun N-terminal kinase (JNK), as well as caspase-dependent apoptosis (2). The C-terminal of TRADD comprises the "death domain" that is responsible for association of TNFR1 and other death domain-containing proteins such as FADD and RIP. The N-terminal domain promotes the recruitment of TRAF2 to TNFR1, leading to the activation of JNK/AP1 and NF-kappa B (1). TRADD is suggested to also be involved in IFN-gamma signaling by forming a complex with STAT1-alpha within the nucleus and regulating IFN-gamma-mediated STAT1-alpha activation (3).
Related PathwayDruggable Genome ApoptosisRIG-I-like receptor signaling pathwayAdipocytokine signaling pathway

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Western blot - TRADD antibody [EPR3604]; All lanes : Anti-TRADD antibody [EPR3604] at 1/500 dilution.Lane 1 : Jurkat cell lysate.Lane 2 : MCF7 cell lysate.Lane 3 : HeLa cell lysate.Lane 4 : K562 cell lysate.Secondary.Goat anti-rabbit HRP conjugated antibody at 1/2000 dilution.Predicted band size : 34 kDa.Observed band size : 34 kDa.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - TRADD antibody [EPR3604]; TA307342, at 1/100, staining TRADD in paraffin-embedded Human breast carcinoma tissue by Immunohistochemistry.
Immunocytochemistry/ Immunofluorescence - TRADD antibody [EPR3604]; TA307342, at 1/100, staining TRADD in HeLa cells by Immunofluorescence.


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