Home All anti-TRADD antibodies
Anti-TRADD Antibody EPR3604
* Buy one primary antibody, get 50% off a GAPDH loading control antibody.
Also for TRADD (NM_003789)
|A synthetic peptide corresponding to residues in human TRADD was used as an immunogen.|
|Human, Mouse, Rat
|WB, IHC, IF
||ICC: 1:100, IHC: 1:100, IP: 1:10, WB: 1:500 - 1,000,
|Store at -20 C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.|
|Homo sapiens TNFRSF1A-associated via death domain (TRADD)|
|TRADD (TNF-R1 associated death domain) is a multifunctional signaling adaptor protein that is essential in recruiting signaling molecules to the TNFR1 receptor complex (1, 3). It mediates TNFR1 activation of NF-kappaB and c-Jun N-terminal kinase (JNK), as well as caspase-dependent apoptosis (2). The C-terminal of TRADD comprises the "death domain" that is responsible for association of TNFR1 and other death domain-containing proteins such as FADD and RIP. The N-terminal domain promotes the recruitment of TRAF2 to TNFR1, leading to the activation of JNK/AP1 and NF-kappa B (1). TRADD is suggested to also be involved in IFN-gamma signaling by forming a complex with STAT1-alpha within the nucleus and regulating IFN-gamma-mediated STAT1-alpha activation (3).|
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Western blot analysis on (A) Jurkat, (B) MCF-7, (C) HeLa and (D) K562 cell lysates using anti-TRADD RabMAb .
Immunohistochemical analysis of paraffin-embedded human breast carcinoma using anti-TRADD RabMAb .
Immunofluorescent staining of HeLa cells using anti-TRADD RabMAb .