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Anti-TRADD Antibody EPR3604


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SKU Description Amount Price Availability*  
  • Rabbit monoclonal antibody against TRADD(clone EPR3604)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC401247) , 20ug Explanation
100ul $325 3 Weeks
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OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human TRADD was used as an immunogen.
Clone NameEPR3604 IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC, IF Suggested DilutionsWB: 1:500 - 1:1000; IP: 1:10; IHC-P: 1:100; ICC: 1:100
Predicted MW Explanation 34 kDa
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Is unsuitable for Flow Cyt.

Reference Data

Target NameHomo sapiens TNFRSF1A-associated via death domain (TRADD)
Alternative NameHs.89862
Database LinkNP_003780
Entrez Gene 8717 Human
Entrez Gene 71609 Mouse
Entrez Gene 246756 Rat
FunctionTRADD (TNF-R1 associated death domain) is a multifunctional signaling adaptor protein that is essential in recruiting signaling molecules to the TNFR1 receptor complex (1, 3). It mediates TNFR1 activation of NF-kappaB and c-Jun N-terminal kinase (JNK), as well as caspase-dependent apoptosis (2). The C-terminal of TRADD comprises the "death domain" that is responsible for association of TNFR1 and other death domain-containing proteins such as FADD and RIP. The N-terminal domain promotes the recruitment of TRAF2 to TNFR1, leading to the activation of JNK/AP1 and NF-kappa B (1). TRADD is suggested to also be involved in IFN-gamma signaling by forming a complex with STAT1-alpha within the nucleus and regulating IFN-gamma-mediated STAT1-alpha activation (3).
Related PathwayDruggable Genome ApoptosisRIG-I-like receptor signaling pathwayAdipocytokine signaling pathway

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* OriGene provides validated application data and protocol, with money back guarantee.

Western blot - TRADD antibody [EPR3604]; All lanes : Anti-TRADD antibody [EPR3604] at 1/500 dilution.Lane 1 : Jurkat cell lysate.Lane 2 : MCF7 cell lysate.Lane 3 : HeLa cell lysate.Lane 4 : K562 cell lysate.Secondary.Goat anti-rabbit HRP conjugated antibody at 1/2000 dilution.Predicted band size : 34 kDa.Observed band size : 34 kDa.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - TRADD antibody [EPR3604]; TA307342, at 1/100, staining TRADD in paraffin-embedded Human breast carcinoma tissue by Immunohistochemistry.
Immunocytochemistry/ Immunofluorescence - TRADD antibody [EPR3604]; TA307342, at 1/100, staining TRADD in HeLa cells by Immunofluorescence.


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