Homo sapiens Fas (TNFRSF6)-associated via death domain (FADD)
Synonyms:
GIG3; MORT1
Immunogen
A synthetic peptide corresponding to residues in human FADD was used as an immunogen.
Buffer
Store at -20C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
Fas-associating protein with death domain (FADD) is an adaptor protein involved in apoptosis induced by Fas, TNF-R1, and mitogen induced cell proliferation (1). FADD consists of a death domain (DD) at the C-terminal and death effector domain (DED) at the N-terminal (2). DD interacts with Fas and TNF-R1, which exposes the DED portion on the FADD. Unmasked DED binds to the DED of pro-caspase-8, which activates the cysteine protease cascade (3). The development of autoimmune lymphoproliferative (lpr) diseases has been linked to the inactivation of Fas-FADD interaction (4). In addition, a deficiency in FADD can inhibit TRAIL-induced cell apoptosis.
Related Pathway
Apoptosis
Toll-like receptor signaling pathway
* Shipping is in business days
* OriGene provides validated application data and protocol, with money back guarantee.
