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Home Antibody All anti-FADD antibodies

Anti-FADD Antibody EPR4415


Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA307340 Rabbit monoclonal antibody against FADD(clone EPR4415) 100ul $325 In Stock
LC401265 FADD HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human FADD was used as an immunogen.
Clone NameEPR4415 IsotypeIgG
Species ReactivityHuman (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1:1000 - 1:10000; IP: 1:10 - 1:100; IHC-P: 1:100 - 1:250; ICC: 1:100 - 1:250
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Note Is unsuitable for Flow Cyt.

Reference Data

Target NameHomo sapiens Fas (TNFRSF6)-associated via death domain (FADD)
Alternative NameGIG3; MORT1
Database LinkNP_003815
Entrez Gene 8772 Human
FunctionFas-associating protein with death domain (FADD) is an adaptor protein involved in apoptosis induced by Fas, TNF-R1, and mitogen induced cell proliferation (1). FADD consists of a death domain (DD) at the C-terminal and death effector domain (DED) at the N-terminal (2). DD interacts with Fas and TNF-R1, which exposes the DED portion on the FADD. Unmasked DED binds to the DED of pro-caspase-8, which activates the cysteine protease cascade (3). The development of autoimmune lymphoproliferative (lpr) diseases has been linked to the inactivation of Fas-FADD interaction (4). In addition, a deficiency in FADD can inhibit TRAIL-induced cell apoptosis.
Related PathwayDruggable Genome ApoptosisToll-like receptor signaling pathwayRIG-I-like receptor signaling pathwayAlzheimer's diseasePathways in cancer

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - FADD antibody [EPR4415]; All lanes : Anti-FADD antibody [EPR4415] at 1/1000 dilution.Lane 1 : A431 cell lysate.Lane 2 : Jurkat cell lysate.Lane 3 : HeLa cell lysate.Lane 4 : SKBR-3 cell lysate.Lysates/proteins at 10 ug per lane.Predicted band size : 23 kDa.

IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - FADD antibody [EPR4415]; Immunohistochemical staining of paraffin-embedded Human kidney tissue using TA307340 at a dilution of 1/100.


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