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Anti-FADD Antibody EPR4415
Also for FADD (NM_003824)
|A synthetic peptide corresponding to residues in human FADD was used as an immunogen.|
||Tissue culture supernatant
||0.5~1.0 mg/ml (Lot Dependent)
||WB: 1:1000 - 1:10000; IP: 1:10 - 1:100; IHC-P: 1:100 - 1:250; ICC: 1:100 - 1:250
|Does not react with Mouse, Rat. Is unsuitable for Flow Cyt.|
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05% (Protein A or G Sepharose)
|Is unsuitable for Flow Cyt.
|Homo sapiens Fas (TNFRSF6)-associated via death domain (FADD)|
|Fas-associating protein with death domain (FADD) is an adaptor protein involved in apoptosis induced by Fas, TNF-R1, and mitogen induced cell proliferation (1). FADD consists of a death domain (DD) at the C-terminal and death effector domain (DED) at the N-terminal (2). DD interacts with Fas and TNF-R1, which exposes the DED portion on the FADD. Unmasked DED binds to the DED of pro-caspase-8, which activates the cysteine protease cascade (3). The development of autoimmune lymphoproliferative (lpr) diseases has been linked to the inactivation of Fas-FADD interaction (4). In addition, a deficiency in FADD can inhibit TRAIL-induced cell apoptosis.|
Toll-like receptor signaling pathway
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Western blot - FADD antibody [EPR4415]; All lanes : Anti-FADD antibody [EPR4415] at 1/1000 dilution.Lane 1 : A431 cell lysate.Lane 2 : Jurkat cell lysate.Lane 3 : HeLa cell lysate.Lane 4 : SKBR-3 cell lysate.Lysates/proteins at 10 µg per lane.Predicted band size : 23 kDa.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - FADD antibody [EPR4415]; Immunohistochemical staining of paraffin-embedded Human kidney tissue using ab108601 at a dilution of 1/100.