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Home Antibody All anti-BAG4 antibodies

Anti-BAG4 Antibody EPR3597

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA307269
  • Rabbit monoclonal antibody against SODD(clone EPR3597)
  • FREE positive control: HEK293T cell transient overexpression lysate (LC417692) , 20ug
100ul $325 3-7 Days
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WB(1)
IHC(2)
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Also for BAG4 (NM_004874)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human SODD was used as an immunogen.
Clone NameEPR3597 IsotypeTissue culture supernatant
Species ReactivityHuman Concentration0.5~1.0 mg/ml (Lot Dependent)
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1:1000 - 1:10000; IHC-P: 1:100 - 1:250; ICC: 1:100 - 1:250
BufferDoes not react with Mouse, Rat. Is unsuitable for Flow Cyt or IP.
Purification pH: 7.40
Preservative: 0.01% Sodium azide
Constituents: 50% Glycerol, 0.05% BSA
Note Is unsuitable for Flow Cyt or IP.

Reference Data

Target NameHomo sapiens BCL2-associated athanogene 4 (BAG4), transcript variant 1
Alternative NameBAG-4; SODD
Database LinkNP_004865
FunctionSODD (BAG4) is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/Hsp70. SODD was found to be associated with the death domain of tumor necrosis factor receptor type 1 (TNF-R1) and death receptor-3 (DR3), and thereby negatively regulates downstream cell death signaling. The regulatory role of this protein in cell death was demonstrated in epithelial cells which undergo apoptosis while integrin mediated matrix contacts are lost (1).
Related Pathway

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WB Image
Western blot - Anti-Silencer of Death Domain antibody [EPR3597]; All lanes : Anti-Silencer of Death Domain antibody [EPR3597] at 1/1000 dilution.Lane 1 : HeLa cell lysate.Lane 2 : MOLT4 cell lysate.Lysates/proteins at 10 µg per lane.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 50 kDa.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Silencer of Death Domain antibody [EPR3597]; Immunohistochemical analysis of paraffin-embedded Human colon adenocarcinoma tissue labelling Silencer of Death Domain with TA307269 at 1/100 dilution.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Silencer of Death Domain antibody [EPR3597]; Immunohistochemical analysis of paraffin-embedded Human kidney tissue labelling Silencer of Death Domain with TA307269 at 1/100 dilution.

 

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