Home All anti-BAG4 antibodies
Anti-BAG4 Antibody EPR3597
* Buy one primary antibody, get 50% off a GAPDH loading control antibody.
Also for BAG4 (NM_004874)
|A synthetic peptide corresponding to residues in human SODD was used as an immunogen.|
||ICC: 1:100 - 250, IHC: 1:100 - 250, WB: 1:1,000 - 10,000,
|Store at -20C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.|
|Homo sapiens BCL2-associated athanogene 4 (BAG4), transcript variant 1|
|SODD (BAG4) is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/Hsp70. SODD was found to be associated with the death domain of tumor necrosis factor receptor type 1 (TNF-R1) and death receptor-3 (DR3), and thereby negatively regulates downstream cell death signaling. The regulatory role of this protein in cell death was demonstrated in epithelial cells which undergo apoptosis while integrin mediated matrix contacts are lost (1).|
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Western blot analysis on (A) HeLa and (B) Molt-4 cell lysates using anti-SODD RabMAb .
Immunohistochemical analysis of paraffin-embedded human colonic adenocarcinoma tissue using anti-SODD RabMAb .