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Home Antibody All anti-BAG4 antibodies

Anti-BAG4 Antibody EPR3596

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA307268
  • Rabbit monoclonal antibody against SODD(clone EPR3596)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC417692) , 20ug
100ul 325 3-7 Days
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WB(1)
IF(1)
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Also for BAG4 (NM_004874)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human SODD was used as an immunogen.
Clone NameEPR3596 IsotypeTissue culture supernatant
Species ReactivityHuman (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IF Suggested DilutionsWB: 1:1000 - 1:10000; FC: 1:10 - 1:100; ICC/IF: 1:100 - 1:250
BufferDoes not react with Mouse, Rat. Is unsuitable for IHC-P or IP.
Purification pH: 7.40
Preservative: 0.01% Sodium azide
Constituents: 50% Glycerol, 0.05% BSA
Note Is unsuitable for IHC-P or IP.

Reference Data

Target NameHomo sapiens BCL2-associated athanogene 4 (BAG4), transcript variant 1
Alternative NameBAG-4; SODD
Database LinkNP_004865
FunctionSODD (Silencer of Death Domain) is a member of the SODD-related protein family. SODD is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/Hsp70. SODD was found to be associated with the death domain of tumor necrosis factor receptor type 1 (TNF-R1) and death receptor-3 (DR3), and thereby negatively regulates downstream cell death signaling. The regulatory role of this protein in cell death was demonstrated in epithelial cells, which undergo apoptosis when integrin mediated matrix contacts are lost.
Related Pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - Silencer of Death Domain antibody [EPR3596]; All lanes : Anti-Silencer of Death Domain antibody [EPR3596] at 1/1000 dilution.Lane 1 : HeLa cell lysate.Lane 2 : HepG2 cell lysate.Lane 3 : Molt-4 cell lysate.Lysates/proteins at 10 ug per lane.Secondary.HRP labelled goat anti-rabbit IgG at 1/2000 dilution.Predicted band size : 50 kDa.Observed band size : 65 kDa .
IF Image
Immunocytochemistry/ Immunofluorescence - Silencer of Death Domain antibody [EPR3596]; Immunofluorescent staining of Silencer of Death Domain in HeLa cells, using TA307268 at a 1/100 dilution.

 

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