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Anti-BAG4 Antibody EPR3596
Also for BAG4 (NM_004874)
|A synthetic peptide corresponding to residues in human SODD was used as an immunogen.|
||Tissue culture supernatant
||Lot dependent; please refer to CoA along with shipment
||WB: 1:1000 - 1:10000; FC: 1:10 - 1:100; ICC/IF: 1:100 - 1:250
|Does not react with Mouse, Rat. Is unsuitable for IHC-P or IP.|
Preservative: 0.01% Sodium azide
Constituents: 50% Glycerol, 0.05% BSA
|Is unsuitable for IHC-P or IP.
|Homo sapiens BCL2-associated athanogene 4 (BAG4), transcript variant 1|
|SODD (Silencer of Death Domain) is a member of the SODD-related protein family. SODD is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/Hsp70. SODD was found to be associated with the death domain of tumor necrosis factor receptor type 1 (TNF-R1) and death receptor-3 (DR3), and thereby negatively regulates downstream cell death signaling. The regulatory role of this protein in cell death was demonstrated in epithelial cells, which undergo apoptosis when integrin mediated matrix contacts are lost.|
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Western blot - Silencer of Death Domain antibody [EPR3596]; All lanes : Anti-Silencer of Death Domain antibody [EPR3596] at 1/1000 dilution.Lane 1 : HeLa cell lysate.Lane 2 : HepG2 cell lysate.Lane 3 : Molt-4 cell lysate.Lysates/proteins at 10 µg per lane.Secondary.HRP labelled goat anti-rabbit IgG at 1/2000 dilution.Predicted band size : 50 kDa.Observed band size : 65 kDa .
Immunocytochemistry/ Immunofluorescence - Silencer of Death Domain antibody [EPR3596]; Immunofluorescent staining of Silencer of Death Domain in HeLa cells, using TA307268 at a 1/100 dilution.