Homo sapiens LIM and senescent cell antigen-like domains 1 (LIMS1), transcript variant 2
Synonyms:
PINCH; PINCH-1; PINCH1
Immunogen
A synthetic peptide corresponding to residues in human LIMS1 was used as an immunogen.
Buffer
Store at -20C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
LIM and senescent cell antigen-like domains 1 (LIMS1, PINCH1) is an adaptor protein that contains five LIM domains. The LIM domain contains two zinc finger motifs that may direct protein-protein interactions (1, 2). LIMS1 is thought to be involved in integrin and growth factor signaling. During integrin signaling, LIMS1 interacts with ILK through its LIM domain. LIMS1 also acts as a bridge linking ILK to NCK2, assisting in growth factor signaling pathways. LIMS1 has been linked to coupling surface receptors to downstream signaling molecules involved in the regulation of cell differentiation, cell proliferation, and cell survival (3).
Related Pathway
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