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Anti-PCYT1A Antibody EPR3941


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SKU Description Amount Price Availability*  
  • Rabbit monoclonal antibody against CCT-alpha(clone EPR3941)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC417575) , 20ug Explanation
100ul $325 3-7 Days
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Also for PCYT1A (NM_005017)
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OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human CCT-alpha was used as an immunogen.
Clone NameEPR3941 IsotypeIgG
Species ReactivityHuman (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IF Suggested DilutionsFC: 1:500 - 1,000, ICC: 1:100 - 250, IP: 1:10 - 100, WB: 1:1,000 - 10,000,
Predicted MW Explanation 42 kDa
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Does not react with Mouse, Rat

Reference Data

Target NameHomo sapiens phosphate cytidylyltransferase 1, choline, alpha (PCYT1A)
Database LinkNP_005008
Entrez Gene 5130 Human
FunctionCTP:phosphocholine cytidylyltransferase (CCT) is the key regulator enzyme in the synthesis of phosphatidylcholine (PC), the most abundant phospholipid in eukaryotic cell membranes. CCT catalyzes the transfer of a cytidylyl group from CTP to phosphocholine to form CDP-choline (1). A steady, albeit low, production of PC is necessary to maintain suitable PC content for lipid homeostasis. However, elevated activity of CCT is required during cell division when increased PC production is needed for membrane biogenesis (2). To date, three CCT isoforms have been identified: CCT-alpha, CCT-beta 1, and CCT-beta 2 (3). CCT-alpha is localized to the nucleus and nuclear envelope in many cell types. An exception is lung-derived cell, where CCT-alpha is localized primarily in cytoplasmic and ER compartments. CCT-alpha is involved in important nuclear functions such as coordinating PC synthesis with cell-cycle regulation and regulating proliferation of the nucleoplasmic reticulum, an intranuclear membrane network implicated in calcium signaling and nuclear-cytoplasmic transport (4).
Related Pathway Glycerophospholipid metabolismMetabolic pathways

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Western blot - PCYT1A antibody [EPR3941]; All lanes : Anti-PCYT1A antibody [EPR3941] at 1/1000 dilution.Lane 1 : A549 cell lysate.Lane 2 : K562 cell lysate.Lane 3 : HeLa cell lysate.Lane 4 : HepG2 cell lysate.Lysates/proteins at 10 ug per lane.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 42 kDa.
Immunocytochemistry/ Immunofluorescence - PCYT1A antibody [EPR3941]; TA307257, at 1/100 dilution, staining PCYT1A in HeLa cells by Immunofluorescence.


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