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Anti-CD80 Antibody EPR1157(2)
Also for CD80 (NM_005191)
|A synthetic peptide corresponding to residues in human B7-1/CD80 was used as an immunogen.|
||Tissue culture supernatant
||0.5~1.0 mg/ml (Lot Dependent)
||WB: 1:1000 - 1:10000; IHC-P: 1:100 - 1:250
|Does not react with Mouse, Rat. Is unsuitable for Flow Cyt,ICC/IF or IP.|
Preservative: 0.01% Sodium azide
Constituents: 50% Glycerol, 0.05% BSA (Protein A or G Sepharose)
|Is unsuitable for Flow Cyt,ICC/IF or IP.
|Homo sapiens CD80 molecule (CD80)|
|B7; B7-1; B7.1; BB1; CD28LG; CD28LG1; LAB7|
|The B-lymphocyte activation antigen B7-1 (CD80) provides regulatory signals for T lymphocytes as a consequence of binding to the CD28 and CTLA4 ligands of T cells. After engagement of T-cell receptor with an antigen in association with MHC class II, a second signal mediated through the binding of B7-1 to CD28 greatly upregulates the production of multiple lymphokines (1). The relatively small CTLA-4/B7-1 binding interface exhibits an unusually high degree of shape complementarity. CTLA-4 forms homodimers through a newly defined interface of highly conserved residues. This zipper-like oligomerization provides the structural basis for forming unusually stable signaling complexes at the T-cell surface, underscoring the importance of potent inhibitory signaling in human immune responses (2).|
Toll-like receptor signaling pathway
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Western blot - Anti-CD80 antibody [EPR1157(2)]; All lanes : Anti-CD80 antibody [EPR1157(2)] at 1/1000 dilution.Lane 1 : Raji cell lysate.Lane 2 : Ramos cell lysate.Lysates/proteins at 10 µg per lane.Secondary.Goat anti-rabbit HRP conjugated antibody at 1/2000 dilution.Predicted band size : 33 kDa.Observed band size : 60 kDa .
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD80 antibody [EPR1157(2)]; Immunohistochemical analysis of paraffin embedded Human tonsil tissue labelling CD80 with ab134120 at 1/100.