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Anti-FGR Antibody EPR3171
|A synthetic peptide corresponding to C-terminus of human FGR was used as an immunogen.|
||Tissue culture supernatant
|Human (Does not react with: Mouse, Rat)
||Lot dependent; please refer to CoA along with shipment
||ICC/IF: 1:10 - 1:100; WB: 1:1000 - 1:10000
|Does not react with Mouse, Rat. Is unsuitable for Flow Cyt,IHC-P or IP.|
Preservative: 0.01% Sodium azide
Constituents: 50% Glycerol, 0.05% BSA
|Is unsuitable for Flow Cyt,IHC-P or IP.
|Homo sapiens FGR proto-oncogene, Src family tyrosine kinase (FGR), transcript variant 1|
|c-fgr; c-src2; p55-Fgr; p55c-fgr; p58-Fgr; p58c-fgr; SRC2|
Entrez Gene 2268 Human
|Fgr (c-fgr) is a member of the Src family of non-receptor protein-tyrosine kinases (PTK’s), which are involved in the intracellular signal transduction for growth and differentiation of the cells. Fgr consists of divergent N-terminal region which is involved in myristylation and palmitylation, conserved SH2 and SH3 internal domain involved in mediating protein-to-protein interactions with phosphotyrosine-containing and proline-rich motifs, and highly conserved C-terminal region tyrosine kinase catalytic domain. Fgr is commonly expressed in cells with hematopoietic origin (e.g. Myeloid cells, NK cells, B cells). Localized in the plasma membrane ruffles, Fgr functions as a negative regulator of cell migration and adhesion triggered by the beta-2 integrin signal transduction pathway. Overexpression of Fgr is seen as a result of Epstein-Barr Virus (EBV) infection (4).|
|Protein KinaseDruggable Genome Chemokine signaling pathway|
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Western blot - Anti-FGR antibody [EPR3171]; Anti-FGR antibody [EPR3171] at 1/1000 dilution + Raji cell lysate at 10 ug.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 59 kDa.