Fgr (c-fgr) is a member of the Src family of non-receptor protein-tyrosine kinases (PTK’s), which are involved in the intracellular signal transduction for growth and differentiation of the cells. Fgr consists of divergent N-terminal region which is involved in myristylation and palmitylation, conserved SH2 and SH3 internal domain involved in mediating protein-to-protein interactions with phosphotyrosine-containing and proline-rich motifs, and highly conserved C-terminal region tyrosine kinase catalytic domain. Fgr is commonly expressed in cells with hematopoietic origin (e.g. Myeloid cells, NK cells, B cells). Localized in the plasma membrane ruffles, Fgr functions as a negative regulator of cell migration and adhesion triggered by the beta-2 integrin signal transduction pathway. Overexpression of Fgr is seen as a result of Epstein-Barr Virus (EBV) infection (4).
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