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Anti-FAIM3 Antibody EPR3811
Also for FAIM3 (NM_005449)
|A synthetic peptide corresponding to residues in human TOSO / FAIM3 was used as an immunogen.|
|Human, Mouse, Rat
||0.5~1.0 mg/ml (Lot Dependent)
||WB: 1:1000 - 1:10000; ICC: 1:50 - 1:100
Preservative: 0.01% Sodium azide
Constituents: 50% Glycerol, 0.05% BSA
|Tissue culture supernatant (Protein A or G Sepharose)
|Is unsuitable for Flow Cyt,IHC-P or IP.
|Homo sapiens Fas apoptotic inhibitory molecule 3 (FAIM3), transcript variant 1|
|Fas apoptotic inhibitory molecule 3 (FAIM3) / TOSO is a single-pass membrane protein that inhibits FAS-induced apoptosis, preventing CASP8 processing through CFLAR up-regulation. FAIM3 / TOSO protects cells from FAS-, TNF alpha- and FADD-induced apoptosis without increasing expression of the inhibitors of apoptosis BCL2 and BCLXL. It seems to activate an inhibitory pathway that prevents CASP8 activation following FAS stimulation, rather than blocking apoptotic signals downstream. FAIM3 / TOSO is specifically expressed in lymph nodes, peripheral blood leukocytes, lung, thymus, and kidneys (1).|
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Western blot - Anti-FAIM3 antibody [EPR3811]; All lanes : Anti-FAIM3 antibody [EPR3811] at 1/1000 dilution.Lane 1 : Human spleen lysate.Lane 2 : Human fetal lung lysate.Lysates/proteins at 10 µg per lane.Secondary.Goat anti-rabbit HRP conjugated antibody at 1/2000 dilution.Predicted band size : 43 kDa.Observed band size : 63 kDa .