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Home Antibody All anti-FRAT1 antibodies

Anti-FRAT1 Antibody EPR3900

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA307216
  • Rabbit monoclonal antibody against FRAT1(clone EPR3900)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC417281) , 20ug Explanation
100ul 325 3-7 Days
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WB(1)

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human FRAT1 was used as an immunogen.
Clone NameEPR3900 IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1:1000 - 1:10000; IP: 1:10 - 1:100; ICC: 1:100 - 1:250; FC: 1:500 - 1:1000
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Is unsuitable for IHC-P.

Reference Data

Target NameHomo sapiens frequently rearranged in advanced T-cell lymphomas 1 (FRAT1)
Alternative NameFLJ97193
Database LinkNP_005470
Entrez Gene 10023 Human
Entrez Gene 14296 Mouse
Entrez Gene 103691373 Rat
FunctionFRAT1 (frequently rearranged in advanced T-cell lymphomas) belongs to the GSK-3-binding protein family. This protein inhibits GSK-3-mediated phosphorylation of beta-catenin and positively regulates the Wnt signaling pathway (1). By binding to GSK3, FRAT1 prevents the phosphorylation and concomitant degradation of beta-catenin; this allows the activation of downstream targets by beta-catenin/TCF complexes (2). It may function in tumor progression and lymphomagenesis (1).
Related PathwayStem cell relevant signaling - Wnt Signaling pathwayES Cell Differentiation/IPSDruggable Genome Wnt signaling pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - FRAT1 antibody [EPR3900]; All lanes : Anti-FRAT1 antibody [EPR3900] at 1/1000 dilution.Lane 1 : HeLa cell lysate .Lane 2 : MCF7 cell lysate .Lysates/proteins at 10 ug per lane.Predicted band size : 29 kDa.

 

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