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Home Antibody All anti-HLA-B antibodies

Anti-HLA-B Antibody EPR2623(2)

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA307215
  • Rabbit monoclonal antibody against HLA-B(clone EPR2623(2))
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC401691) , 20ug
100ul 325 3-7 Days
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WB(1)
IHC(1)
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Also for HLA-B (NM_005514)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in the extracellular domain of human HLA-B was used as an immunogen.
Clone NameEPR2623(2) IsotypeTissue culture supernatant
Species ReactivityHuman (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1:1000 - 1:10000; IHC-P: 1:250 - 1:500
BufferDoes not react with Mouse, Rat. Is unsuitable for Flow Cyt,ICC or IP.
Purification PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Note Is unsuitable for Flow Cyt,ICC or IP.

Reference Data

Target NameHomo sapiens major histocompatibility complex, class I, B (HLA-B)
Alternative NameAS; HLAB; SPDA1
Database LinkNP_005505
FunctionHLA-B belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide; exon 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide; exon 4 encodes the alpha3 domain; exon 5 encodes the transmembrane region; and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class I molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-B alleles have been described (1).
Related Pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - HLA B7 antibody [EPR2623(2)]; All lanes : Anti-HLA B7 antibody [EPR2623(2)] at 1/1000 dilution.Lane 1 : Jurkat Ramos cell lysate.Lane 2 : HL60 cell lysate.Lane 3 : TF1 cell lysate.Lane 4 : Ramos cell lysate.Lysates/proteins at 10 ug per lane.Predicted band size : 40 kDa.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - HLA B7 antibody [EPR2623(2)]; TA307215 at 1/250 dilution staining HLA B7 in Human tonsil by Immunohistochemistry, Paraffin-embedded tissue.

 

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