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Home Antibody All anti-HLA-B antibodies

Anti-HLA-B Antibody EPR2623(2)


Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA307215 Rabbit monoclonal antibody against HLA-B(clone EPR2623(2)) 100ul $325 3-7 Days
LC401691 HLA HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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Also for HLA-B (NM_005514)
cDNA Clone shRNA/siRNA CRISPR KO Kit Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in the extracellular domain of human HLA-B was used as an immunogen.
Clone NameEPR2623(2) IsotypeIgG
Species ReactivityHuman (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application * Suggested DilutionsWB: 1:1000 - 1:10000; IHC-P: 1:250 - 1:500
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Note Is unsuitable for Flow Cyt,ICC or IP.

Reference Data

Target NameHomo sapiens major histocompatibility complex, class I, B (HLA-B)
Alternative NameAS; HLAB; SPDA1
Database LinkNP_005505
Entrez Gene 3106 Human
FunctionHLA-B belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide; exon 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide; exon 4 encodes the alpha3 domain; exon 5 encodes the transmembrane region; and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class I molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-B alleles have been described (1).
Related PathwayTransmembrane EndocytosisCell adhesion molecules (CAMs)Antigen processing and presentationNatural killer cell mediated cytotoxicityType I diabetes mellitusAutoimmune thyroid diseaseMore Pathways >>

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.


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