Home Antibody All anti-HLA-B antibodies
Anti-HLA-B Antibody EP2624
Also for HLA-B (NM_005514)
|A synthetic peptide corresponding to residues in human HLA-B was used as an immunogen.|
||Tissue culture supernatant
|Human (Does not react with: Mouse, Rat)
||Lot dependent; please refer to CoA along with shipment
||WB: 1:1000 - 1:10000; IP: 1:10 - 1:100
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Is unsuitable for Flow Cyt.
|Homo sapiens major histocompatibility complex, class I, B (HLA-B)|
|AS; HLAB; SPDA1|
Entrez Gene 3106 Human
|HLA-B belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide; exon 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide; exon 4 encodes the alpha3 domain; exon 5 encodes the transmembrane region; and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class I molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-B alleles have been described.|
|Transmembrane EndocytosisCell adhesion molecules (CAMs)Antigen processing and presentationNatural killer cell mediated cytotoxicityType I diabetes mellitusAutoimmune thyroid diseaseMore Pathways >> |
* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.
Western blot - Anti-MHC class I + HLA B [EP2624] antibody; All lanes : Anti-MHC class I + HLA B [EP2624] antibody at 1/1000 dilution.Lane 1 : Ramos cell lysate.Lane 2 : HL 60 cell lysate .Lane 3 : Jurkat cell lysate .Lane 4 : TF1 cell lysate.Lysates/proteins at 10 ug per lane.Secondary.Goat anti-rabbit HRP conjugated antibody at 1/2000 dilution.Predicted band size : 40 kDa.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MHC class I + HLA B [EP2624] antibody; TA307214, at 1/100, staining HLA B in paraffin embedded Human tonsils by Immunohistochemistry.