Homo sapiens LIM domain only 2 (rhombotin-like 1) (LMO2), transcript variant 1
Synonyms:
RBTN2; RBTNL1; RHOM2; TTG2
Immunogen
A synthetic peptide corresponding to residues in human LMO2 was used as an immunogen.
Buffer
Store at -20C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
LMO2 (LIM-only protein 2, RBNT2), a member of the LIM-only class of transcriptional co-regulators that consist of two closely spaced cysteine-rich LIM domains has distinct functions in erythropoiesis and in T-cell leukemogenesis. These diverse functions of LMO2 are presumed to be accomplished through physical interaction with different with different protein partners that bind the LIM domains of LMO2 (1). It is also required for early stages of hematopoiesis, and the LMO2 master gene encodes a protein that has a central and crucial role in the hematopoietic development (2). LMO2 has been identified as a novel oncogene associated with carcinogenesis and prognosis in several malignant tumors (3)
Related Pathway
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