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Anti-TERF2 Antibody EPR3517(2)
Also for TERF2 (NM_005652)
|A synthetic peptide corresponding to residues in human TRF2 was used as an immunogen.|
||Tissue culture supernatant
||0.5~1.0 mg/ml (Lot Dependent)
|WB, IHC, IF
||WB: 1:1000 - 1:10000; IHC-P: 1:250 - 1:500; ICC/IF: 1:100 - 1:250
|Does not react with Mouse, Rat. Is unsuitable for Flow Cyt or IP.|
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05% (Protein A or G Sepharose)
|Is unsuitable for Flow Cyt or IP.
|Homo sapiens telomeric repeat binding factor 2 (TERF2)|
|Telomeric repeat-binding factor 2 (TRF2) is a component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection (1). Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protection, telomeres are no longer hidden from DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways (1). TRF2 and TRF1, along with their interaction partners, reorganize the chromosome end into a T-loop, a protected structure, to hide the end of the chromosome (2). TRF2 can also recruit RAP1 to telomeres in order to inhibit non-homologous end joining (NHEJ) (3). In addition, TRF2 is ubiquitously expressed with high expression in the spleen, thymus, and colon (1).|
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Western blot - TRF2 antibody [EPR3517(2)]; All lanes : Anti-TRF2 antibody [EPR3517(2)] at 1/1000 dilution.Lane 1 : HT29 cell lysate.Lane 2 : HeLa cell lysate.Lane 3 : Jurkat cell lysate.Lysates/proteins at 10 µg per lane.Predicted band size : 56 kDa.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - TRF2 antibody [EPR3517(2)]; ab108997 at 1/250 dilution staining TRF2 in Human spleen by Immunohistochemistry, Paraffin-embedded tissue.
Immunocytochemistry/ Immunofluorescence - TRF2 antibody [EPR3517(2)]; ab108997 at 1/100 dilution staining TRF2 in HeLa cells by Immunofluorescence.