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Home Antibody All anti-OLIG2 antibodies

Anti-OLIG2 Antibody EPR2673

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA307193
  • Rabbit monoclonal antibody against OLIG2(clone EPR2673)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC417055) , 20ug
100ul 325 In Stock
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WB(1)
IHC(1)
Assay(1)
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Also for OLIG2 (NM_005806)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human OLIG2 was used as an immunogen.
Clone NameEPR2673 IsotypeTissue culture supernatant
Species ReactivityHuman ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, ASSAY, IHC Suggested DilutionsWB: 1:1000 - 1:10000; IP: 1:10 - 1:100; IHC-P: 1:100 - 1:250
BufferDoes not react with Rat. Is unsuitable for Flow Cyt or ICC.
Purification PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Note Is unsuitable for Flow Cyt or ICC.

Reference Data

Target NameHomo sapiens oligodendrocyte lineage transcription factor 2 (OLIG2)
Alternative NameBHLHB1; bHLHe19; OLIGO2; PRKCBP2; RACK17
Database LinkNP_005797
FunctionOLIG2 is a transcription factor with basic helix-loop-helix (bHLH) domains that have fundamental roles during neuronal and glial production (1). It is required for oligodendrocyte and motor neuron specification in the spinal cord, as well as for the development of somatic motor neurons in the hindbrain (2). As a result, it plays a critical role in motor neuron and oligodendrocyte fate specification during development (3). It cooperates with OLIG1 to establish the pMN domain of the embryonic neural tube (2). In addition, interaction between OLIG2 and Nkx2.2 during neuronogenesis helps to establish the pMN-p3 boundary in the developing spinal cord and promote the maturation of oligodendrocyte progenitor cells (1). The expression of OLIG2 is normally restricted to neural tissues; however, overexpression of OLIG2 has been shown in patients with precursor T-cell lymphoblastic lymphoma/leukemia (5).
Related Pathway

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WB Image
Western blot - Olig2 antibody [EPR2673]; Anti-Olig2 antibody [EPR2673] at 1/1000 dilution + Oligodendroglioma lysate at 10 µg.Performed under reducing conditions.Predicted band size : 32 kDa.
Assay Image
Other-Anti-Olig2 antibody [EPR2673](TA307193); Equilibrium disassociation constant (KD)..
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Olig2 antibody [EPR2673]; TA307193, at 1/100, staining Olig2 in Human glioma tissue by immunohistochemistry.

 

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