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Anti-OLIG2 Antibody EPR2673
Also for OLIG2 (NM_005806)
|A synthetic peptide corresponding to residues in human OLIG2 was used as an immunogen.|
|Mouse, Human (Does not react with: Rat)
||Lot dependent; please refer to CoA along with shipment
|WB, ASSAY, IHC
||WB: 1:1000 - 1:10000; IP: 1:10 - 1:100; IHC-P: 1:100 - 1:250
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Is unsuitable for Flow Cyt or ICC.
|Homo sapiens oligodendrocyte lineage transcription factor 2 (OLIG2)|
|BHLHB1; bHLHe19; OLIGO2; PRKCBP2; RACK17|
Entrez Gene 10215 Human
Entrez Gene 50913 Mouse
|OLIG2 is a transcription factor with basic helix-loop-helix (bHLH) domains that have fundamental roles during neuronal and glial production (1). It is required for oligodendrocyte and motor neuron specification in the spinal cord, as well as for the development of somatic motor neurons in the hindbrain (2). As a result, it plays a critical role in motor neuron and oligodendrocyte fate specification during development (3). It cooperates with OLIG1 to establish the pMN domain of the embryonic neural tube (2). In addition, interaction between OLIG2 and Nkx2.2 during neuronogenesis helps to establish the pMN-p3 boundary in the developing spinal cord and promote the maturation of oligodendrocyte progenitor cells (1). The expression of OLIG2 is normally restricted to neural tissues; however, overexpression of OLIG2 has been shown in patients with precursor T-cell lymphoblastic lymphoma/leukemia (5).|
|Transcription FactorsDruggable Genome |
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Western blot - Olig2 antibody [EPR2673]; Anti-Olig2 antibody [EPR2673] at 1/1000 dilution + Oligodendroglioma lysate at 10 ug.Performed under reducing conditions.Predicted band size : 32 kDa.
Other-Anti-Olig2 antibody [EPR2673](TA307193); Equilibrium disassociation constant (KD)..
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Olig2 antibody [EPR2673]; TA307193, at 1/100, staining Olig2 in Human glioma tissue by immunohistochemistry.