Novel HIF2A mutations disrupt oxygen sensing, leading to polycythemia, paragangliomas, and somatostatinomas Blood, Mar 2013; 121: 2563 - 2566.
[anti-HA]
Regulation of the PI3-K/Akt Survival Pathway in the Rat Endometrium Biol Reprod, Mar 2013; 88: 79.
[Akt3]
RNA elements directing in vivo assembly of the 7SK/MePCE/Larp7 transcriptional regulatory snRNP Nucleic Acids Res., Mar 2013; 10.1093/nar/gkt159.
[LA]
Ruxolitinib as potential targeted therapy for patients with JAK2 rearrangements Haematologica, Mar 2013; 98: 404 - 408.
[JAK2]
Homo sapiens microtubule-associated protein tau (MAPT), transcript variant 2
Synonyms:
DDPAC; FTDP-17; MAPTL; MSTD; MTBT1; MTBT2; PPND; TAU
Immunogen
A synthetic phospho-peptide corresponding to residues surrounding Serine 199 of human Tau was used as immunogen. The antibody only detects Tau phosphorylated on Serine 199.
Buffer
Store at -20C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
Tau is a microtubule binding protein that promotes microtubule assembly and stability. Tau is found to be the major component of the paired helical filaments (PHFs) found in the brains of patients with Alzheimer disease (AD) (1, 2). Tau is hyperphosphorylated at least 25 different sites in PHFs, and specific phosphorylation sites have been implicated in the loss of Taus association with the membrane cortex during AD disease state, including Ser 199/202, Thr 231, and Ser 393/404 (3). CDK5, GSK3 beta, and TTBK1 have been linked to phosphorylation on Ser 199, which can induce tau aggregation and inhibit tau interaction with Fyn (4,5). With up to 9 different isoforms of Tau, Ser 199 corresponds to the most popular isoform, called isoform 8.
Related Pathway
MAPK signaling pathway
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