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Anti-MAPT PHOSPHO Antibody EPR2401Y
Also for MAPT (NM_016841)
|A synthetic phospho-peptide corresponding to residues surrounding Serine 199 of human Tau was used as immunogen. The antibody only detects Tau phosphorylated on Serine 199.|
|Human, Mouse, Rat
||0.5~1.0 mg/ml (Lot Dependent)
||WB: 1:5000 - 1:20000
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Tissue culture supernatant (Protein A or G Sepharose)
|Homo sapiens microtubule-associated protein tau (MAPT), transcript variant 4|
|DDPAC; FTDP-17; MAPTL; MSTD; MTBT1; MTBT2; PPND; TAU|
|Tau is a microtubule binding protein that promotes microtubule assembly and stability. Tau is found to be the major component of the paired helical filaments (PHFs) found in the brains of patients with Alzheimer disease (AD) (1, 2). Tau is hyperphosphorylated at least 25 different sites in PHFs, and specific phosphorylation sites have been implicated in the loss of Taus association with the membrane cortex during AD disease state, including Ser 199/202, Thr 231, and Ser 393/404 (3). CDK5, GSK3 beta, and TTBK1 have been linked to phosphorylation on Ser 199, which can induce tau aggregation and inhibit tau interaction with Fyn (4,5). With up to 9 different isoforms of Tau, Ser 199 corresponds to the most popular isoform, called isoform 8.|
MAPK signaling pathway
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Western blot - Anti-Tau (phospho S199) antibody [EPR2401Y]; All lanes : Anti-Tau (phospho S199) antibody [EPR2401Y] at 1/20000 dilution.Lane 1 : SH SY5Y cell lysate.Lane 2 : SH SY5Y cell lysate treated with alkaline phosphatase.Lysates/proteins at 10 µg per lane.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 79 kDa.Observed band size : 55 kDa .