Tau is a microtubule binding protein that promotes microtubule assembly and stability. Tau is found to be the major component of the paired helical filaments (PHFs) found in the brains of patients with Alzheimer disease (AD) (1, 2). Tau is hyperphosphorylated at least 25 different sites in PHFs, and specific phosphorylation sites have been implicated in the loss of Taus association with the membrane cortex during AD disease state, including Ser 199/202, Thr 231, and Ser 393/404 (3). CDK5, GSK3 beta, and TTBK1 have been linked to phosphorylation on Ser 199, which can induce tau aggregation and inhibit tau interaction with Fyn (4,5). With up to 9 different isoforms of Tau, Ser 199 corresponds to the most popular isoform, called isoform 8.
MAPK signaling pathway
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