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Anti-RUVBL2 Antibody EPR4146
Also for RUVBL2 (NM_006666)
|A synthetic peptide corresponding to residues in human RUVBL2 was used as an immunogen.|
||Tissue culture supernatant
||Lot dependent; please refer to CoA along with shipment
||WB: 1:1000 - 1:10000
|Does not react with Rat. Is unsuitable for Flow Cyt,ICC,IHC-P or IP.|
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
|Is unsuitable for Flow Cyt,ICC,IHC-P or IP.
|Homo sapiens RuvB-like AAA ATPase 2 (RUVBL2)|
|CGI-46; ECP51; INO80J; REPTIN; RVB2; TIH2; TIP48; TIP49B|
|RuvB-like 2 (RUVBL2), also called Reptin or TIP49B, is a DNA helicase of the AAA+ ATPase family that is involved in double-strand break repair (1). It is a component of the NuA4 histone acetyltransferase complex, which controls transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A (2). This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with other proteins that positively regulate transcription (2). The complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction; tumor suppressor mediated growth arrest; and replicative senescence, apoptosis, and DNA repair (2). RUVBL2 is ubiquitously expressed, at the highest levels in the testis and thymus (2).|
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Western blot - Reptin/TIP49B/RUVB2 antibody [EPR4146]; All lanes : Anti-Reptin/TIP49B/RUVB2 antibody [EPR4146] at 1/1000 dilution.Lane 1 : HepG2 cell lysate.Lane 2 : Daudi cell lysate.Lane 3 : HeLa cell lysate.Lane 4 : SKBR-3 cell lysate.Lysates/proteins at 10 µg per lane.Predicted band size : 51 kDa.