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Anti-RUVBL2 Antibody EPR4146


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SKU Description Amount Price Availability*  
  • Rabbit monoclonal antibody against RUVBL2(clone EPR4146)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC401993) , 20ug Explanation
100ul $325 3-7 Days
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Also for RUVBL2 (NM_006666)
cDNA Clone shRNA/siRNA CRISPR KO Kit Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human RUVBL2 was used as an immunogen.
Clone NameEPR4146 IsotypeIgG
Species ReactivityMouse, Human (Does not react with: Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1:1000 - 1:10000
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Note Is unsuitable for Flow Cyt,ICC,IHC-P or IP.

Reference Data

Target NameHomo sapiens RuvB-like AAA ATPase 2 (RUVBL2)
Alternative NameCGI-46; ECP51; INO80J; REPTIN; RVB2; TIH2; TIP48; TIP49B
Database LinkNP_006657
Entrez Gene 10856 Human
Entrez Gene 20174 Mouse
FunctionRuvB-like 2 (RUVBL2), also called Reptin or TIP49B, is a DNA helicase of the AAA+ ATPase family that is involved in double-strand break repair (1). It is a component of the NuA4 histone acetyltransferase complex, which controls transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A (2). This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with other proteins that positively regulate transcription (2). The complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction; tumor suppressor mediated growth arrest; and replicative senescence, apoptosis, and DNA repair (2). RUVBL2 is ubiquitously expressed, at the highest levels in the testis and thymus (2).
Related PathwayTranscription Factors

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* OriGene provides validated application data and protocol, with money back guarantee.

Western blot - Reptin/TIP49B/RUVB2 antibody [EPR4146]; All lanes : Anti-Reptin/TIP49B/RUVB2 antibody [EPR4146] at 1/1000 dilution.Lane 1 : HepG2 cell lysate.Lane 2 : Daudi cell lysate.Lane 3 : HeLa cell lysate.Lane 4 : SKBR-3 cell lysate.Lysates/proteins at 10 ug per lane.Predicted band size : 51 kDa.


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