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Home Antibody All anti-RUVBL2 antibodies

Anti-RUVBL2 Antibody EPR4146

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA307149
  • Rabbit monoclonal antibody against RUVBL2(clone EPR4146)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC401993) , 20ug
100ul 325 3-7 Days
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WB(1)
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Also for RUVBL2 (NM_006666)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human RUVBL2 was used as an immunogen.
Clone NameEPR4146 IsotypeTissue culture supernatant
Species ReactivityHuman, Mouse ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1:1000 - 1:10000
BufferDoes not react with Rat. Is unsuitable for Flow Cyt,ICC,IHC-P or IP.
Purification PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Note Is unsuitable for Flow Cyt,ICC,IHC-P or IP.

Reference Data

Target NameHomo sapiens RuvB-like AAA ATPase 2 (RUVBL2)
Alternative NameCGI-46; ECP51; INO80J; REPTIN; RVB2; TIH2; TIP48; TIP49B
Database LinkNP_006657
FunctionRuvB-like 2 (RUVBL2), also called Reptin or TIP49B, is a DNA helicase of the AAA+ ATPase family that is involved in double-strand break repair (1). It is a component of the NuA4 histone acetyltransferase complex, which controls transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A (2). This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with other proteins that positively regulate transcription (2). The complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction; tumor suppressor mediated growth arrest; and replicative senescence, apoptosis, and DNA repair (2). RUVBL2 is ubiquitously expressed, at the highest levels in the testis and thymus (2).
Related Pathway

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WB Image
Western blot - Reptin/TIP49B/RUVB2 antibody [EPR4146]; All lanes : Anti-Reptin/TIP49B/RUVB2 antibody [EPR4146] at 1/1000 dilution.Lane 1 : HepG2 cell lysate.Lane 2 : Daudi cell lysate.Lane 3 : HeLa cell lysate.Lane 4 : SKBR-3 cell lysate.Lysates/proteins at 10 µg per lane.Predicted band size : 51 kDa.

 

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