Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein (APP) by two proteases, one of which is BACE1. BACE1 is a member of the peptidase A1 protein family, a type I integral membrane glycoprotein and aspartic protease that is found mainly in the Golgi (1).
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