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Anti-TBK1 Antibody EPR2867(2)-19
Also for TBK1 (NM_013254)
|A synthetic peptide corresponding to residues in human NAK / TBK1 was used as an immunogen.|
|Human, Mouse, Rat
||0.5~1.0 mg/ml (Lot Dependent)
|WB, IHC, IF
||WB: 1:1000 - 1:10000; IHC-P: 1:250 - 1:500; FC: 1:10 - 1:100; ICC/IF: 1:100 - 1:250
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Tissue culture supernatant (Protein A or G Sepharose)
|Is unsuitable for IP.
|Homo sapiens TANK-binding kinase 1 (TBK1)|
|NFkappaB-activating kinase (NAK), also known as TANK binding kinase-1 (TBK1) or tumor necrosis factor receptor−associated factor 2-associated kinase (T2K), is a serine/threonine kinase that belongs to the IkB kinase (IKK) family (1). Similar to IKK alpha and beta, NAK induces IkB degradation and NF-kB activity (2). NAK is activated by phorbol ester tumor promoters and growth factors, whereas catalytically inactive NAK specifically inhibits activation of NF-kB by protein kinase C-epsilon (PKCepsilon). NAK specifically phosphorylates IkB alpha on Serine 36 and NFkB subunit RelA (p65) on Serine 536 (3). NAK is also known to interact with TANK, TRAF-2 and TRIF (4).|
Toll-like receptor signaling pathway
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Western blot - Anti-NAK [EPR2867(2)-19] antibody; All lanes : Anti-NAK [EPR2867(2)-19] antibody at 1/1000 dilution.Lane 1 : HeLa cell lysate.Lane 2 : U937 cell lysate.Lane 3 : HepG2 cell lysate.Lane 4 : 293T cell lysate.Lysates/proteins at 10 µg per lane.Predicted band size : 84 kDa.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NAK [EPR2867(2)-19] antibody; Immunohistochemical analysis of paraffin-embedded Human testis tissue using ab109735 at a dilution of 1/250.
Immunocytochemistry/ Immunofluorescence - Anti-NAK [EPR2867(2)-19] antibody; Immunofluorescent staining of HeLa cells using ab109735 at a dilution of 1/100.