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Anti-TBK1 Antibody EPR2867(2)-19


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SKU Description Amount Price Availability*  
  • Rabbit monoclonal antibody against NAK / TBK1(clone EPR2867(2))
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC415713) , 20ug Explanation
100ul $325 3-7 Days
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OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human NAK / TBK1 was used as an immunogen.
Clone NameEPR2867(2)-19 IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC, IF Suggested DilutionsWB: 1:1000 - 1:10000; IHC-P: 1:250 - 1:500; FC: 1:10 - 1:100; ICC/IF: 1:100 - 1:250
Predicted MW Explanation 84 kDa
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Is unsuitable for IP.

Reference Data

Target NameHomo sapiens TANK-binding kinase 1 (TBK1)
Alternative NameNAK; T2K
Database LinkNP_037386
Entrez Gene 29110 Human
Entrez Gene 56480 Mouse
Entrez Gene 299827 Rat
FunctionNFkappaB-activating kinase (NAK), also known as TANK binding kinase-1 (TBK1) or tumor necrosis factor receptor−associated factor 2-associated kinase (T2K), is a serine/threonine kinase that belongs to the IkB kinase (IKK) family (1). Similar to IKK alpha and beta, NAK induces IkB degradation and NF-kB activity (2). NAK is activated by phorbol ester tumor promoters and growth factors, whereas catalytically inactive NAK specifically inhibits activation of NF-kB by protein kinase C-epsilon (PKCepsilon). NAK specifically phosphorylates IkB alpha on Serine 36 and NFkB subunit RelA (p65) on Serine 536 (3). NAK is also known to interact with TANK, TRAF-2 and TRIF (4).
Related PathwayProtein KinaseDruggable Genome Toll-like receptor signaling pathwayRIG-I-like receptor signaling pathwayCytosolic DNA-sensing pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - Anti-NAK [EPR2867(2)-19] antibody; All lanes : Anti-NAK [EPR2867(2)-19] antibody at 1/1000 dilution.Lane 1 : HeLa cell lysate.Lane 2 : U937 cell lysate.Lane 3 : HepG2 cell lysate.Lane 4 : 293T cell lysate.Lysates/proteins at 10 ug per lane.Predicted band size : 84 kDa.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NAK [EPR2867(2)-19] antibody; Immunohistochemical analysis of paraffin-embedded Human testis tissue using TA307114 at a dilution of 1/250.
IF Image
Immunocytochemistry/ Immunofluorescence - Anti-NAK [EPR2867(2)-19] antibody; Immunofluorescent staining of HeLa cells using TA307114 at a dilution of 1/100.


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