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Home Antibody All anti-TBK1 antibodies

Anti-TBK1 Antibody EPR2867(2)-19

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA307114
  • Rabbit monoclonal antibody against NAK / TBK1(clone EPR2867(2))
  • FREE positive control: HEK293T cell transient overexpression lysate (LC415713) , 20ug
100ul $325 3-7 Days
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WB(1)
IHC(1)
IF(1)
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Also for TBK1 (NM_013254)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human NAK / TBK1 was used as an immunogen.
Clone NameEPR2867(2)-19 IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration0.5~1.0 mg/ml (Lot Dependent)
Guaranteed Application *WB, IHC, IF Suggested DilutionsWB: 1:1000 - 1:10000; IHC-P: 1:250 - 1:500; FC: 1:10 - 1:100; ICC/IF: 1:100 - 1:250
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Is unsuitable for IP.

Reference Data

Target NameHomo sapiens TANK-binding kinase 1 (TBK1)
Alternative NameNAK; T2K
Database LinkNP_037386
FunctionNFkappaB-activating kinase (NAK), also known as TANK binding kinase-1 (TBK1) or tumor necrosis factor receptor−associated factor 2-associated kinase (T2K), is a serine/threonine kinase that belongs to the IkB kinase (IKK) family (1). Similar to IKK alpha and beta, NAK induces IkB degradation and NF-kB activity (2). NAK is activated by phorbol ester tumor promoters and growth factors, whereas catalytically inactive NAK specifically inhibits activation of NF-kB by protein kinase C-epsilon (PKCepsilon). NAK specifically phosphorylates IkB alpha on Serine 36 and NFkB subunit RelA (p65) on Serine 536 (3). NAK is also known to interact with TANK, TRAF-2 and TRIF (4).
Related Pathway
Toll-like receptor signaling pathway

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* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - Anti-NAK [EPR2867(2)-19] antibody; All lanes : Anti-NAK [EPR2867(2)-19] antibody at 1/1000 dilution.Lane 1 : HeLa cell lysate.Lane 2 : U937 cell lysate.Lane 3 : HepG2 cell lysate.Lane 4 : 293T cell lysate.Lysates/proteins at 10 µg per lane.Predicted band size : 84 kDa.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NAK [EPR2867(2)-19] antibody; Immunohistochemical analysis of paraffin-embedded Human testis tissue using TA307114 at a dilution of 1/250.
IF Image
Immunocytochemistry/ Immunofluorescence - Anti-NAK [EPR2867(2)-19] antibody; Immunofluorescent staining of HeLa cells using TA307114 at a dilution of 1/100.

 

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