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Anti-KSR1 PHOSPHO Antibody EP2358Y


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SKU Description Amount Price Availability*  
  • Rabbit monoclonal antibody against KSR1 Phospho (pS404) (clone EP1305Y ) (Phospho-Specific)
100ul $325 3-7 Days
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OriGene Data

ImmunogenA synthetic phospho-peptide corresponding to residues surrounding Serine 404 of human KSR1 was used as immunogen
Clone NameEP2358Y IsotypeIgG
Species ReactivityHuman (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IF Suggested DilutionsWB: 1:1000 - 1:10000; ICC: 1:100 - 1:250
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Note Is unsuitable for Flow Cyt,IHC-P or IP.

Reference Data

Target NameHomo sapiens kinase suppressor of ras 1 (KSR1)
Alternative NameKSR; RSU2
Database LinkNP_055053
Entrez Gene 8844 Human
FunctionKinase suppressor of Ras (KSR) is a conserved component of the Ras pathway that interacts directly with MEK and MAPK. It has been shown that KSR1 translocates from the cytoplasm to the cell surface in response to growth factor treatment and that this process is regulated by MARK3 (1). MARK3 phosphorylates serine 309 and serine 404 on KSR1. While, PPP2CA dephosphorlyates serine 404 on KSR1. MARK3 seems to be a positive regulator of the beta-catenin pathway and an inhibitor of the JNK pathway. These findings show that MARK3, a regulator of polarity, is also a modulator of Wnt-beta-catenin signalling, indicating a link between two important developmental pathways (2).
Related PathwayProtein KinaseDruggable Genome

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Western blot - KSR1 (phospho S404) antibody [EP2358Y]; All lanes : Anti-KSR1 (phospho S404) antibody [EP2358Y] at 1/2000 dilution.Lane 1 : HeLa cell lysate (untreated).Lane 2 : HeLa cell lysate, treated with Calyculin A.Lysates/proteins at 10 ug per lane.Secondary.goat anti-rabbit HRP labelled IgG at 1/1000 dilution.Predicted band size : 102 kDa.Observed band size : 110 kDa .
Immunocytochemistry/ Immunofluorescence - KSR1 (phospho S404) antibody [EP2358Y]; Immunofluorescent staining of Sh-SY-5Y cells, using TA307110, at 1/100 dilution.


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