Novel HIF2A mutations disrupt oxygen sensing, leading to polycythemia, paragangliomas, and somatostatinomas Blood, Mar 2013; 121: 2563 - 2566.
[anti-HA]
Regulation of the PI3-K/Akt Survival Pathway in the Rat Endometrium Biol Reprod, Mar 2013; 88: 79.
[Akt3]
RNA elements directing in vivo assembly of the 7SK/MePCE/Larp7 transcriptional regulatory snRNP Nucleic Acids Res., Mar 2013; 10.1093/nar/gkt159.
[LA]
Ruxolitinib as potential targeted therapy for patients with JAK2 rearrangements Haematologica, Mar 2013; 98: 404 - 408.
[JAK2]
Human class II major histocompatibility complex (MHC) products are essential initiators of cellular immune responses. Their cell surface expression demonstrates aspects of tissue-restriction, inducibility, differentiation-dependence, and coordinate regulation indicative of complex molecular controls mediated primarily at the level of transcription (1). There are three major isotypes of human class II MHC molecules; HLA-DR, HLA-DP, and HLA-DQ, each of which consists of an alpha and beta chain (2). HLA-DR alpha is a polymorphic cell surface glycoprotein that is crucial for the cellular interaction in immune response. Class II molecules have limited tissue distribution and are predominantly expressed on B lymphocytes and macrophage and present peptides derived from extracellular proteins to T cells (3).
Related Pathway
Hematopoietic cell lineage
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