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Home Antibody All anti-OTX2 antibodies

Anti-OTX2 Antibody EPR3348


Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA307061 Rabbit monoclonal antibody against OTX2(clone EPR3348) 100ul $325 In Stock
LC411946 OTX2 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human OTX2 was used as an immunogen.
Clone NameEPR3348 IsotypeIgG
Species ReactivityHuman (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1:1,000 - 10,000,
Predicted MW Explanation 32 kDa
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Does not react with Mouse, Rat

Reference Data

Target NameHomo sapiens orthodenticle homeobox 2 (OTX2), transcript variant 1
Alternative NameCPHD6; MCOPS5
Database LinkNP_068374
Entrez Gene 5015 Human
FunctionHomeobox protein OTX2 is a member of the bicoid sub-family of homeodomain-containing transcription factors. It acts as a transcription factor and is reported to play a role in brain and sensory organ development (1); more specifically, forebrain and eye development (2). The OTX2 is required to determine mesencephalic versus metencephalic (cerebellum/pons) territory during embryogenesis. This function of OTX2 primarily involves positioning and maintaining the mid-hindbrain organizer at the border between midbrain and anterior hindbrain (3). OTX2 is expressed during development in the neuroepithelium of most of the forebrain and midbrain, including the eye domain. In mice, complete elimination of the OTX2 function results in the absence of the forebrain and embryonic lethality (4). Defects in OTX2 are the caused of microphthalmia syndromic type 5, a clinically heterogeneous disorder of the eye formation (5).
Related PathwayStem cell - PluripotencyEmbryonic stem cellsInduced pluripotent stem cellsTranscription Factors

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Western blot - Otx2 antibody [EPR3348]; Anti-Otx2 antibody [EPR3348] at 1/1000 dilution + Y79 cell lysate at 10 ug.Secondary.HRP labelled goat anti-rabbit IgG at 1/1000 dilution.Predicted band size : 32 kDa.


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