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Home Antibody All anti-TCL1A antibodies

Anti-TCL1A Antibody EPR3949

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA307059
  • Rabbit monoclonal antibody against TCL1(clone EPR3949)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC411851) , 20ug
100ul 325 3-7 Days
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WB(1)
IHC(6)
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Also for TCL1A (NM_021966)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human TCL1 was used as an immunogen.
Clone NameEPR3949 IsotypeTissue culture supernatant
Species ReactivityHuman (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1:1000 - 1:10000; IHC-P: 1:100 - 1:250; ICC: 1:100 - 1:250; FC: 1:10 - 1:100
BufferDoes not react with Mouse, Rat. Is unsuitable for IP.
Purification PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Note Is unsuitable for IP.

Reference Data

Target NameHomo sapiens T-cell leukemia/lymphoma 1A (TCL1A), transcript variant 1
Alternative NameTCL1
Database LinkNP_068801
FunctionT-cell leukemia/lymphoma protein 1A (TCL1) is a member of the TCL1 family and enhances the phosphorylation and activation of AKT1, AKT2 and AKT3. TCL1 promotes nuclear translocation of AKT1 and enhances cell proliferation, stabilizes mitochondrial membrane potential and promotes cell survival. It is a homodimer that interacts with PNPT1; the interaction has no effect on PNPT1 exonuclease activity. TCL1 is restricted in the T-cell lineage to immature thymocytes and activated peripheral lymphocytes. It is preferentially expressed early in T- and B-lymphocyte differentiation. Chromosomal aberrations activating TCL1A are found in chronic T-cell leukemias (T-CLL) (1).
Related Pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - Tcl1 antibody [EPR3949]; All lanes : Anti-Tcl1 antibody [EPR3949] at 1/1000 dilution.Lane 1 : Daudi cell lysate.Lane 2 : Ramos cell lysates.Lysates/proteins at 10 ug per lane.Secondary.Standard HRP labelled goat anti-goat. at 1/2000 dilution.Predicted band size : 13 kDa.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Tcl1 antibody [EPR3949]; Immunohistochemical analysis of paraffin-embedded Human tonsil tissue using TA307059.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)-Anti-Tcl1 antibody [EPR3949](TA307059); TA307059 showing negative staining in Skeletal muscle tissue.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)-Anti-Tcl1 antibody [EPR3949](TA307059); TA307059 showing positive staining in Normal spleen tissue.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)-Anti-Tcl1 antibody [EPR3949](TA307059); TA307059 showing negative staining in Normal brain tissue.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)-Anti-Tcl1 antibody [EPR3949](TA307059); TA307059 showing negative staining in Normal kidney tissue.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)-Anti-Tcl1 antibody [EPR3949](TA307059); TA307059 showing negative staining in Normal stomach tissue.

 

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