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OriGene Antibodies in recent publications
A common polymorphism in the LDL receptor gene has multiple effects on LDL receptor function Hum. Mol. Genet., Apr 2013; 22: 1424 - 1431. [anti-DDK]
Excitotoxicity Upregulates SARM1 Protein Expression and Promotes Wallerian-Like Degeneration of Retinal Ganglion Cells and Their Axons Invest. Ophthalmol. Vis. Sci., Apr 2013; 54: 2771 - 2780. [SARM1]
Modulation of TET2 expression and 5-methylcytosine oxidation by the CXXC domain protein IDAX Nature 497, 122-126 doi:10.1038/nature12052 [anti-DDK]
Natriuretic Peptide Receptor-3 Gene (NPR3): Nonsynonymous Polymorphism Results in Significant Reduction in Protein Expression Because of Accelerated Degradation Circ Cardiovasc Genet, Apr 2013; 6: 201 - 210. [NPR3]
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 Home All anti-NEUROG2 antibodies

Anti-NEUROG2 Antibody EPR4177

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Specifications Related Products Conjugation/Bulk FAQs
SKU Description Amount Price Availability*  
TA307052
  • Rabbit monoclonal antibody against Neurogenin-2(clone EPR4177)
  • FREE positive control: HEK293T cell transient overexpression lysate (LC411396) , 20ug
 100ul $325 3-7 Days Add to Shopping Cart
WB(1)
IF(1)
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Also for NEUROG2 (NM_024019)
cDNA Clone shRNA/siRNA Lysate Protein Request Antibody
Gene NameHomo sapiens neurogenin 2 (NEUROG2)
Synonyms:Atoh4; bHLHa8; Math4A; ngn-2; NGN2
ImmunogenA synthetic peptide corresponding to residues in human Neurogenin-2 was used as an immunogen.
Buffer50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Clone NameEPR4177 IsotypeRabbit IgG
Species ReactivityHuman, Mouse, Rat Concentration
Guaranteed Application *WB, IF Suggested DilutionsICC: 1:100 - 250, WB: 1:1,000 - 10,000,
BackgroundNeurogenin-2 (Ngn-2) is a member of the neurogenin subfamily of basic helix-loop-helix (bHLH) transcription factors that play an important role in neurogenesis from migratory neural crest cells (1). In particular, it is critical for the differentiation and survival of midbrain dopaminergic neurons (2). Neurogenin-2, in collaboration with extrinsic signal retinoic acid (RA), triggers transcriptionally active chromatin in spinal motor neurons during development (3). Neurogenin-2 is bound by Retinoic acid receptor (RAR), and RAR is thereby recruited to motor neuron genes targeted by Neurogenin-2 (3). RA then facilitates the recruitment of a histone acetyltransferase CBP to the Neurogenin-2/RAR-complex, markedly inducing histone H3/H4-acetylation (3).
Related Pathway

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* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis on (A) SH-SY5Y and (B) HepG2 cell lysates using anti-Neurogenin-2 RabMAb .
IF Image
Immunofluorescent staining of SH-SY-5Y cells using anti-Neurogenin-2 RabMAb .

 

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