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Anti-NEUROG2 Antibody EPR4177
Also for NEUROG2 (NM_024019)
|A synthetic peptide corresponding to residues in human Neurogenin-2 was used as an immunogen.|
|Mouse, Rat, Human
||Lot dependent; please refer to CoA along with shipment
||ICC/IF: 1:100 - 1:250; WB: 1:1000 - 1:10000
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Tissue culture supernatant
|Is unsuitable for Flow Cyt,IHC-P or IP.
|Homo sapiens neurogenin 2 (NEUROG2)|
|Atoh4; bHLHa8; Math4A; ngn-2; NGN2|
Entrez Gene 63973 Human
Entrez Gene 11924 Mouse
Entrez Gene 295475 Rat
|Neurogenin-2 (Ngn-2) is a member of the neurogenin subfamily of basic helix-loop-helix (bHLH) transcription factors that play an important role in neurogenesis from migratory neural crest cells (1). In particular, it is critical for the differentiation and survival of midbrain dopaminergic neurons (2). Neurogenin-2, in collaboration with extrinsic signal retinoic acid (RA), triggers transcriptionally active chromatin in spinal motor neurons during development (3). Neurogenin-2 is bound by Retinoic acid receptor (RAR), and RAR is thereby recruited to motor neuron genes targeted by Neurogenin-2 (3). RA then facilitates the recruitment of a histone acetyltransferase CBP to the Neurogenin-2/RAR-complex, markedly inducing histone H3/H4-acetylation (3).|
|Transcription Factors |
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Western blot - Neurogenin 2 antibody [EPR4177]; All lanes : Anti-Neurogenin 2 antibody [EPR4177] at 1/1000 dilution.Lane 1 : SH-SY5Y cell lysate.Lane 2 : HepG2 cell lysate.Lysates/proteins at 10 ug per lane.Predicted band size : 29 kDa.
Immunocytochemistry/ Immunofluorescence - Neurogenin 2 antibody [EPR4177]; Immunofluorescent staining of Neurogenin 2 in SH-SY-5Y cells using TA307052 at 1/100 dilution.