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Home Antibody All anti-BRCC3 antibodies

Anti-BRCC3 Antibody EPR4366

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Specifications Citations (0) Related Products Product Documents
SKU Description Amount Price Availability*  
TA307049 Rabbit monoclonal antibody against BRCC36(clone EPR4366) 100ul $325 In Stock
LC411291 BRCC3 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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WB(1)
FC(1)

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human BRCC36 was used as an immunogen.
Clone NameEPR4366 IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, FC Suggested DilutionsWB: 1:10000 - 1:50000; IP: 1:10 - 1:100; FC: 1:100 - 1:500
Predicted MW Explanation 36 kDa
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Is unsuitable for ICC or IHC-P.

Reference Data

Target NameHomo sapiens BRCA1/BRCA2-containing complex, subunit 3 (BRCC3), transcript variant 1
Alternative NameBRCC36; C6.1A; CXorf53
Database LinkNP_077308
Entrez Gene 79184 Human
Entrez Gene 210766 Mouse
Entrez Gene 316794 Rat
FunctionBRCC36 is a subunit of the BRCA1-BRCA2-containing complex (BRCC), which is an E3 ubiquitin ligase. It is a metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains, and does not have activity toward 'Lys-48'-linked polyubiquitin chains. In the BRCA1-A complex, it specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX, antagonizing the RNF8-dependent ubiquitination at double-strand breaks (DSBs). This protein is also thought to be involved in the cellular response to ionizing radiation and progression through the G2/M checkpoint (1).
Related PathwayProteaseDruggable Genome

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Western blot - BRCC36 antibody [EPR4366]; All lanes : Anti-BRCC36 antibody [EPR4366] at 1/10000 dilution.Lane 1 : HeLa cell lysate.Lane 2 : MCF7 cell lysate.Lane 3 : SKBR-3 cell lysate.Lane 4 : 293T cell lysate.Lysates/proteins at 10 ug per lane.Predicted band size : 36 kDa.
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Flow Cytometry - BRCC36 antibody [EPR4366]; Flow cytometric analysis of BRCC36 in permeabilized HeLa cells, using TA307049 at a 1/100 dilution (red) or a Rabbit IgG (negative) (green).
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