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Home Antibody All anti-BRCC3 antibodies

Anti-BRCC3 Antibody EPR4365

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA307048
  • Rabbit monoclonal antibody against BRCC36(clone EPR4365)
  • FREE positive control: HEK293T cell transient overexpression lysate (LC411291) , 20ug
100ul 325 3-7 Days
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WB(1)

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human BRCC36 was used as an immunogen.
Clone NameEPR4365 IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration0.5~1.0 mg/ml (Lot Dependent)
Guaranteed Application *WB Suggested DilutionsWB: 1:1000 - 1:10000; IP: 1:10 - 1:100; ICC: 1:50 - 1:100
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Is unsuitable for Flow Cyt or IHC-P.

Reference Data

Target NameHomo sapiens BRCA1/BRCA2-containing complex, subunit 3 (BRCC3), transcript variant 1
Alternative NameBRCC36; C6.1A; CXorf53
Database LinkNP_077308
FunctionBRCC36 is a subunit of the BRCA1-BRCA2-containing complex (BRCC), which is an E3 ubiquitin ligase. (1). It is a metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains, and does not have activity toward 'Lys-48'-linked polyubiquitin chains. In the BRCA1-A complex, it specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX, antagonizing the RNF8-dependent ubiquitination at double-strand breaks (DSBs). BRCC36 is expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. It is aberrantly expressed in the vast majority of breast tumors (2). This protein is also thought to be involved in the cellular response to ionizing radiation and progression through the G2/M checkpoint (1).
Related Pathway

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WB Image
Western blot - BRCC36 antibody [EPR4365]; All lanes : Anti-BRCC36 antibody [EPR4365] at 1/1000 dilution.Lane 1 : MCF7 cell lysate.Lane 2 : SKBR3 cell lysate.Lane 3 : 293T cell lysate.Lane 4 : Human fetal kidney lysate.Lane 5 : HeLa cell lysate.Lysates/proteins at 10 µg per lane.Predicted band size : 36 kDa.

 

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