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OriGene Antibodies in recent publications
A common polymorphism in the LDL receptor gene has multiple effects on LDL receptor function Hum. Mol. Genet., Apr 2013; 22: 1424 - 1431. [anti-DDK]
Excitotoxicity Upregulates SARM1 Protein Expression and Promotes Wallerian-Like Degeneration of Retinal Ganglion Cells and Their Axons Invest. Ophthalmol. Vis. Sci., Apr 2013; 54: 2771 - 2780. [SARM1]
Modulation of TET2 expression and 5-methylcytosine oxidation by the CXXC domain protein IDAX Nature 497, 122-126 doi:10.1038/nature12052 [anti-DDK]
Natriuretic Peptide Receptor-3 Gene (NPR3): Nonsynonymous Polymorphism Results in Significant Reduction in Protein Expression Because of Accelerated Degradation Circ Cardiovasc Genet, Apr 2013; 6: 201 - 210. [NPR3]
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 Home All anti-BRCC3 antibodies

Anti-BRCC3 Antibody EPR4365

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Specifications Related Products Conjugation/Bulk FAQs
SKU Description Amount Price Availability*  
TA307048
  • Rabbit monoclonal antibody against BRCC36(clone EPR4365)
  • FREE positive control: HEK293T cell transient overexpression lysate (LC411291) , 20ug
 100ul $325 3-7 Days Add to Shopping Cart
WB(1)
Gene NameHomo sapiens BRCA1/BRCA2-containing complex, subunit 3 (BRCC3), transcript variant 1
Synonyms:BRCC36; C6.1A; CXorf53; RP11-143H17.2
ImmunogenA synthetic peptide corresponding to residues in human BRCC36 was used as an immunogen.
Buffer50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Clone NameEPR4365 IsotypeRabbit IgG
Species ReactivityHuman, Mouse, Rat Concentration
Guaranteed Application *WB Suggested DilutionsICC: 1:50 - 100, IP: 1:10 - 100, WB: 1:1,000 - 10,000,
BackgroundBRCC36 is a subunit of the BRCA1-BRCA2-containing complex (BRCC), which is an E3 ubiquitin ligase. (1). It is a metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains, and does not have activity toward 'Lys-48'-linked polyubiquitin chains. In the BRCA1-A complex, it specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX, antagonizing the RNF8-dependent ubiquitination at double-strand breaks (DSBs). BRCC36 is expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. It is aberrantly expressed in the vast majority of breast tumors (2). This protein is also thought to be involved in the cellular response to ionizing radiation and progression through the G2/M checkpoint (1).
Related Pathway

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* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis on (A) MCF-7, (B) SKBR-3, (C) 293T, (D) fetal kidney, and (E) HeLa cell lysates using anti-BRCC36 RabMAb .

 

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