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Anti-TCF7L1 Antibody EPR2031
Also for TCF7L1 (NM_031283)
|A synthetic peptide corresponding to residues in human TCF-3 was used as an immunogen.|
||Tissue culture supernatant
||Lot dependent; please refer to CoA along with shipment
||WB: 1:1000 - 1:5000; FC: 1:100
|Does not react with Mouse, Rat. Is unsuitable for ICC/IF,IHC-P or IP.|
Preservative: 0.01% Sodium azide
Constituents: 50% Glycerol, 0.05% BSA
|Is unsuitable for ICC/IF,IHC-P or IP.
|Homo sapiens transcription factor 7-like 1 (T-cell specific, HMG-box) (TCF7L1)|
|T-cell factor 3 (transcription factor 7-like 1, TCF-3) is a component of the Wnt signaling pathway, which functions in CNS patterning, proliferation and neurogenesis, and a dominant downstream effector in embryonic stem cells (ESCs). TCF-3 binds to and represses the Oct4 promoter, and plays an important role in modulating the appropriate level of gene transcription in ESCs and during embryonic development (1, 2). TCF-3 is necessary for the terminal differentiation of epidermal cells, the formation of keratohyalin granules and the development of the barrier function of the epidermis. It down-regulates NQO1, leading to increased mitomycin c resistance. It is detected in hair follicles and skin keratinocytes, and at lower levels in stomach epithelium (2). |
Wnt Signaling Pathway
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Western blot - Anti-TCF7L1 antibody [EPR2031]; All lanes : Anti-TCF7L1 antibody [EPR2031] at 1/1000 dilution.Lane 1 : A431 lysate.Lane 2 : Human fetal small intestine lysate.Lysates/proteins at 10 µg per lane.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 63 kDa.