Musahi2 (Msi2) is a member of Musashi family of evolutionarily conserved RNA-binding proteins. In mammals, Musahi1 and 2 shares similar primary structure, RNA binding specificity, and expression profile during CNS development. Highly co-expressed with Musahi1 in neural precursor cells, Musahi2 has been linked to proliferation and maintenance of stem cells in central nervous system. With two conserved tandem RNA recognition motifs, Musashi2 binds to target mRNAs and regulates RNA expression at translation level (1). Chromosomal aberrations involving Mushahi2 might play a role in disease progression for chronic myeloid leukemia (2).
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