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Anti-STAT1 Antibody EPYR2154

WB(1)

Gene Name Homo sapiens signal transducer and activator of transcription 1, 91kDa (STAT1), transcript variant beta Synonyms: CANDF7; ISGF-3; STAT91 Immunogen A synthetic peptide corresponding to residues in human Stat-1 was used as an immunogen. Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Clone Name EPYR2154 Isotype Rabbit IgG Species Reactivity Human, Mouse Concentration Purification (Protein A or G Sepharose) Guaranteed Application * WB Suggested Dilutions FC: 1:50, IP: 1:50, WB: 1:1000 - 2000, Background Stat-1 is a latent transcription factor that functions both as a signal transducer in the cytoplasm and an activator of transcription in the nucleus. Stat-1 is one of seven members of the Signal transducer and activators of transcription (Stats) family (1). Stat-1 is activated by a different number of ligands; IFN?, IFN?, EGF, PDGF and IL6 (2-3). Upon tyrosine phosphorylation, Stat-1 dimerize with Stat-2 and associates with ISGF3/IR9 to form the ISGF3 complex (4). This activation subsequently allows the complex to translocate to the nucleus & bind specific enhancer elements. Additional complexes can form upon IFN stimulation (1). Related Pathway Adipogenesis EGFR1 Signaling Pathway Jak-STAT signaling pathway TGF Beta Signaling Pathway Toll-like receptor signaling pathway

Related Lysate from OriGene • Transient overexpression lysate of signal transducer and activator of transcription 1, 91kDa (STAT1), transcript variant beta Anti-Tag Antibodies & WB Reagent • Anti-Tag Antibodies • Western Blot Reagent shRNA • STAT1 - Human, 4 unique 29mer shRNA constructs in retroviral RFP vector • STAT1 - Human, 4 unique 29mer shRNA constructs in retroviral GFP vector • Stat1 - Mouse, 4 unique 29mer shRNA constructs in retroviral GFP vector • STAT1 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector • Stat1 - Mouse, 4 unique 29mer shRNA constructs in retroviral untagged vector Related ORF Clones • Myc-DDK-tagged ORF clone of Homo sapiens signal transducer and activator of transcription 1, 91kDa (STAT1), transcript variant beta as transfection-ready DNA • GFP-tagged ORF clone of Homo sapiens signal transducer and activator of transcription 1, 91kDa (STAT1), transcript variant beta as transfection-ready DNA Related cDNA Clones • Homo sapiens signal transducer and activator of transcription 1, 91kDa (STAT1), transcript variant beta as transfection-ready DNA

Conjugation Services
OriGene provides conjugation services of TrueMAB antibodies with the following molecules:

• HRP
• Biotin
• PE
• FITC
• DyLight® 488
• DyLight® 550
• DyLight® 594
• DyLight® 633

* DyLight is a trademark of Thermo-Fisher Scientific

Bulk Order
OriGene offers bulk sizes of TrueMAB antibodies in both the BSA/glycerol formulation and the carrier-free (BSA/glycerol-free) formulation.

Contact us with your conjugation/bulk request: antibody@origene.com or 888-267-4436 (Tech Support)