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Anti-DNMT3B Antibody EPR3523


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SKU Description Amount Price Availability*  
TA306991 Rabbit monoclonal antibody against Dnmt3b (clone EPR3523 ) 100ul $325 In Stock
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OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human Dnmt3b was used as an immunogen.
Clone NameEPR3523 IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1:1000 - 1:5000; ICC/IF: 1:50 - 1:100
Predicted MW Explanation 96 kDa
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Is unsuitable for Flow Cyt,IHC-P or IP.

Reference Data

Target NameHomo sapiens DNA (cytosine-5-)-methyltransferase 3 beta (DNMT3B), transcript variant 2
Alternative NameICF; ICF1; M.HsaIIIB
Database LinkNP_787044
Entrez Gene 1789 Human
Entrez Gene 13436 Mouse
Entrez Gene 444985 Rat
FunctionDNA (cytosine-5)-methyltransferase 3B (Dnmt3b) is a DNA methyltransferase that is essential for mammalian development potentially through its transcription and repression activity (1). It is one of three different families of DNA (cytosine-5) methyltransferases, Dnmt1, Dnmt2, Dnmt3 (Dnmt3a and Dnmt3b). Dnmt3a and Dnmt3b form complexes with the major maintenance enzyme Dnmt1 (2). Depletion of Dnmt3b has been shown to induce apoptosis of human cancer cells, and reactivate methylation-silenced gene expression (3). Methylation defects in ICF syndrome may also result from impaired stimulation of Dnmt3b activity (4).
Related PathwayStem cell - PluripotencyEmbryonic stem cellsInduced pluripotent stem cellsDruggable Genome Cysteine and methionine metabolismMetabolic pathways

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Western blot - Anti-Dnmt3b antibody; All lanes : Anti-Dnmt3b antibodyat 1/1000 dilution. Lane 1 : Flag-tagged Dnmt3b.Lane 2 : Dnmt3b knockout mouse embryonic stem cell extract.Lane 3 : Wild type mouse embryonic stem cell extract.Lane 4 : Wild type mouse embryonic stem cell extract.Lysates/proteins at 40 ug per lane.
Western blot - Dnmt3b antibody [EPR3523]; All lanes : Anti-Dnmt3b antibody [EPR3523] at 1/5000 dilution.Lane 1 : A549 cell lysate.Lane 2 : HeLa cell lysate.Lane 3 : A431 cell lysate.Lysates/proteins at 10 ug per lane.Secondary.Goat anti-rabbit HRP conjugate at 1/2000 dilution.Predicted band size : 96 kDa.Observed band size : 96 kDa.


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