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Anti-EGFR PHOSPHO Antibody E124


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SKU Description Amount Price Availability*  
TA306974 Rabbit monoclonal antibody against EGFR Phospho (pY1173)(clone E124) (Phospho-Specific) 100ul $325 3-7 Days
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OriGene Data

ImmunogenA synthetic phospho-peptide corresponding to residues surrounding Tyr1173 of human EGF receptor was used as immunogen. The antibody detects EGFR phosphorylated on Tyrosine 1173 of the mature human isoform 1 (corresponding to Y1197 from the precursor form
Clone NameE124 IsotypeIgG
Species ReactivityHuman (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application * Suggested DilutionsICC: 1:25-50, IHC: 1:25-50, IP: 1:10, WB: 1:1,000-10,000,
Predicted MW Explanation 170 kDa
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Note Does not react with Mouse, Rat

Reference Data

Target NameHomo sapiens epidermal growth factor receptor (EGFR), transcript variant 1
Alternative NameERBB; ERBB1; HER1; mENA; NISBD2; PIG61
Database LinkNP_005219
Entrez Gene 1956 Human
FunctionEpidermal growth factor receptor (EGFR) is a 170 kDa transmembrane glycoprotein receptor tyrosine kinase that, activated by epidermal growth factor (EGF), affects cell growth and differentiation (1). Binding of EGF or TGF alpha to EGFR activates tyrosine kinase activity of the receptor (2). The carboxy terminal tyrosine residues on EGFR, Tyr 1068, Tyr 1148, and Tyr 1173, are the major sites of autophosphorylation, which occurs as a result of EGF binding (3). Once activated, EGFR phosphotyrosines Y-1068 and Y-1173 mediate the binding of Grb2 to the EGFR. Addtionally, phosphotyrosine Y-1173 is a major binding site for SHC on the EGFR (4).
Related PathwayStem cell relevant signaling - JAK/STAT signaling pathwayProtein KinaseSecreted ProteinES Cell Differentiation/IPSTransmembraneAdult stem cellsCancer stem cellsDruggable Genome MAPK signaling pathwayErbB signaling pathwayCalcium signaling pathwayCytokine-cytokine receptor interactionEndocytosisDorso-ventral axis formationMore Pathways >>

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.


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