Home Antibody All anti-NANOG antibodies
Also for NANOG (NM_024865)
|NANOG antibody was raised against a 19 amino acid peptide near the center of human NANOG.|
|Human, Mouse, Rat
||ELISA, WB: 1 - 2 ug/ml, IHC: 5 ug/ml, IF: 20 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column
|Homo sapiens Nanog homeobox (NANOG), transcript variant 1|
|homeobox transcription factor Nanog; homeobox transcription factor Nanog-delta 48; Nanog homeobox|
Entrez Gene 79923 Human
Entrez Gene 71950 Mouse
Entrez Gene 414065 Rat
|Expression of NANOG is required for the maintenance of pluripotency in epiblast and embryonic stem (ES) cells as well as for the ability to maintain ES self-renewal independently of LIF/Stat3. The role of NANOG in embryonic development suggested that it might be useful in the creation of stem cells that might be useful in cell replacement therapies in the treatment of several degenerative diseases. Artificial stem cells, termed induced pluripotent stem (iPS) cells, can be created by expressing POU5F1 (also known as Oct-4), another germline-specific transcription factor, and the transcription factors Sox2, Klf4 and Lin28 along with c-Myc in mouse fibroblasts. More recently, experiments have demonstrated that iPS cells could be generated using expression plasmids expressing NANOG, Sox2, KlfF4 and c-Myc, eliminating the need for virus introduction, thereby addressing a safety concern for potential use of iPS cells in regenerative medicine.|
|ES Cell Differentiation/IPSStem cell - PluripotencyCancer stem cellsEmbryonic stem cellsInduced pluripotent stem cells |
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Western blot analysis of NANOG in human spleen tissue lysate with NANOG antibody at (A) 1 and (B) 2 ug/mL.
Immunohistochemistry of NANOG in human spleen tissue with NANOG antibody at 5 ug/mL.