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Home Antibody All anti-PRDM16 antibodies

Anti-PRDM16 Antibody


Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA306900 Rabbit Polyclonal PRDM16 Antibody 100ug $325 In Stock
LC411786 PRDM16 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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Also for PRDM16 (NM_022114)
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OriGene Data

ImmunogenPRDM16 antibody was raised against a 17 amino acid peptide from near the carboxy terminus of human PRDM16.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC, IF Suggested DilutionsWB: 1 - 2 ug/mL, ICC: 2.5 ug/mL, IF: 20 ug/mL
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NamePR domain 16
Alternative NameCMD1LL|LVNC8|MEL1|PFM13
Database LinkNP_071397
Entrez Gene 63976 Human
Entrez Gene 70673 Mouse
Entrez Gene 100366024 Rat
FunctionPRDM16 is a zinc finger transcription factor and contains an N-terminal PR domain. The reciprocal translocation t(1;3)(p36;q21) occurs in a subset of myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). This gene is located near the 1p36.3 breakpoint and has been shown to be specifically expressed in the t(1:3)(p36,q21)-positive MDS/AML. The translocation results in the overexpression of a truncated version of this protein that lacks the PR domain, which may play an important role in the pathogenesis of MDS and AML. Recent studies have shown that PRDM16 normally acts as a Smad3 binding protein that may be important for the development of orofacial structures through modulation of the TGF-beta signaling pathway. Other experiments have indicated that PRDM16 controls a bidirectional cell fate switch between skeletal myoblasts and brown fat cells.
Related Pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of PRDM16 in rat brain tissue lysate with PRDM16 antibody at (A) 1 and (B) 2 ug/mL.

IHC Image
Immunohistochemistry of PRDM16 in rat brain tissue with PRDM16 antibody at 2.5 ug/mL.

IF Image
Immunofluorescence of PRDM16 in Human Brain cells with PRDM16 antibody at 20 ug/mL.


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