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Home Antibody All anti-PLEKHM3 antibodies

Anti-PLEKHM3 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306875
  • Rabbit Polyclonal PLEKHM3 Antibody
100ug $325 3-7 Days
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WB(1)
IHC(1)
IF(1)
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Also for PLEKHM3 (NM_001080475)
cDNA Clone shRNA/siRNA Primer Pair Protein Request Antibody

OriGene Data

ImmunogenPLEKHM3 antibody was raised against a 13 amino acid peptide from near the carboxy terminus of human PLEKHM3.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB, IHC, IF Suggested DilutionsWB: 1 - 2 ug/ml, IHC: 5 ug/ml, IF: 20 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens pleckstrin homology domain containing, family M, member 3 (PLEKHM3)
Alternative NameDAPR; PLEKHM1L
Database LinkNP_001073944
FunctionPLEKHM3, also known as DAPR, is a member of the M family of Pleckstrin homology domain-containing proteins. PLEKHM3 was initially identified through chromatin immunoprecipitation and CpG microarray analysis examining proteins regulated by myocyte-enhancing factor 2. In C2C12 myoblast cells, PLEKHM3 binds to the PI3K signaling member protein kinase B in the cytosol prior to differentiation into myotubes. Following the initiation of differentiation, PLEKHM3 was also found in membrane fractions. Knockdown of PLEKHM3 expression by RNAi resulted in the inhibition of myotube formation, suggesting that PLEKHM3 is a key component required by myoblasts for orchestrating their differentiation during myogenesis.
Related Pathway

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WB Image
Western blot analysis of PLEKHM3 in mouse skeletal muscle tissue lysate with PLEKHM3 antibody at (A) 1 and (B) 2 µg/ml.
IHC Image
Immunohistochemistry of PLEKHM3 in human brain tissue with PLEKHM3 antibody at 5 ug/ml.
IF Image
Immunofluorescence of PLKHM3 in human brain tissue with PLKHM3 antibody at 20 ug/mL.

 

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