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Home Antibody All anti-INSM1 antibodies

Anti-INSM1 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306849
  • Rabbit Polyclonal IA-1 Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC419479) , 20ug
100ug 325 3-7 Days
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WB(1)
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Also for INSM1 (NM_002196)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenIA-1 antibody was raised against a 19 amino acid peptide from near the amino terminus of human IA-1.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB Suggested DilutionsWB: 1 - 2 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens insulinoma-associated 1 (INSM1)
Alternative NameIA-1; IA1
Database LinkNP_002187
FunctionIA-1, also known as INSM1, is an essential five zinc-finger transcription factor that while initially identified from an insulinoma cDNA library, is expressed in the developing nervous system. Specifically, IA-1 is expressed as early as E9.5 in mice in the fore-, mid- and hindbrain, spinal cord, retina, and olfactory bulb. It is thought that IA-1 functions as a transcriptional repressor, and is a part of several signaling pathways including those of Notch and sonic hedgehog in addition to that of Ngn3 during pancreatic endocrine cell differentiation. IA-1 is also expressed in multiple tumors, including the majority of neuroendocrine tumors tested so far as well as nearly 100% of all small cell lung carcinomas, indicating that IA-1 may be an important target in cancer therapy.
Related Pathway

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WB Image
Western blot analysis of IA-1 in rat thymus tissue lysate with IA-1 antibody at 1 µg/ml.

 

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