Home Antibody All anti-INSM1 antibodies
Also for INSM1 (NM_002196)
|IA-1 antibody was raised against a 19 amino acid peptide from near the amino terminus of human IA-1.|
|Human, Mouse, Rat
||WB: 1 - 2 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column
|Homo sapiens insulinoma-associated 1 (INSM1)|
Entrez Gene 3642 Human
Entrez Gene 53626 Mouse
Entrez Gene 366210 Rat
|IA-1, also known as INSM1, is an essential five zinc-finger transcription factor that while initially identified from an insulinoma cDNA library, is expressed in the developing nervous system. Specifically, IA-1 is expressed as early as E9.5 in mice in the fore-, mid- and hindbrain, spinal cord, retina, and olfactory bulb. It is thought that IA-1 functions as a transcriptional repressor, and is a part of several signaling pathways including those of Notch and sonic hedgehog in addition to that of Ngn3 during pancreatic endocrine cell differentiation. IA-1 is also expressed in multiple tumors, including the majority of neuroendocrine tumors tested so far as well as nearly 100% of all small cell lung carcinomas, indicating that IA-1 may be an important target in cancer therapy.|
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Western blot analysis of IA-1 in rat thymus tissue lysate with IA-1 antibody at 1 µg/ml.