Home Antibody All anti-KDM3A antibodies
Also for KDM3A (NM_001146688)
|JMJD1A antibody was raised against a 16 amino acid peptide from near the amino terminus of human JMJD1A.|
|Human, Mouse, Rat
||WB: 1 - 2 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column
|Homo sapiens lysine (K)-specific demethylase 3A (KDM3A), transcript variant 2|
|JHDM2A; JHMD2A; JMJD1; JMJD1A; TSGA|
Entrez Gene 55818 Human
Entrez Gene 104263 Mouse
Entrez Gene 312440 Rat
|The jumonji domain containing 1A protein (JMJD1A) was originally discovered as a testes specific gene, but has been found to be expressed in numerous tissues. JMJD1A is a histone demethylase and specifically demethylates mono- and dimethyl-H3K9. It has also been found to be a novel interaction partner with ER71, a transcription factor expressed in the testes of adult mice and during embryogenesis. JMJD1A is also a downstream gene of STAT3, a protein that has been found to be important in the maintenance of mouse embryonic stem (mES) cells, and decreased JMJD1A expression correlated with the differentiation of cultured mES cells following the removal of the cytokine LIF. These findings suggest that JMJD1A might be a critical signaling molecule underlying the maintenance of pluripotency in embryonic stem cells. At least two isoforms of JMJD1A are known to exist. This antibody will not cross-react with JMJD1B or JMJD1C.|
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Western blot analysis of JMJD1A in mouse liver tissue lysate with JMJD1A antibody at (A) 1 and (B) 2 µg/ml.
Immunohistochemistry of JMJD1A in rat liver tissue with JMJD1A antibody at 5 ug/ml.