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Home Antibody All anti-NOTUM antibodies

Anti-NOTUM Antibody

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Specifications Citations (0) Related Products Product Documents
SKU Description Amount Price Availability*  
TA306819
  • Rabbit Polyclonal NOTUM Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC405887) , 20ug Explanation
100ug $325 In Stock
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WB(1)
IHC(1)
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Also for NOTUM (NM_178493)
cDNA Clone shRNA/siRNA CRISPR KO Kit Protein Antibody

OriGene Data

ImmunogenNOTUM antibody was raised against a 19 amino acid peptide near the amino terminus of human NOTUM.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1mg/ml
Guaranteed Application *WB, IHC Suggested DilutionsWB: 0.5 - 1 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens notum pectinacetylesterase homolog (Drosophila) (NOTUM)
Alternative Namenotum
Database LinkNP_848588
Entrez Gene 147111 Human
Entrez Gene 77583 Mouse
Entrez Gene 303743 Rat
FunctionIn Drosophila, the notum gene is regulated by the Wingless pathway and encodes a secreted hydrolase that modifies heparan sulfate proteoglycans. The mammalian homolog has been shown to be able to cleave glypicans and can release GPI-anchored proteins from the mammalian cell surface. Like the Drosophilia NOTUM, the mammalian protein can act as a negative regulator of the Wnt signaling pathway. NOTUM is expressed at a low level in most mammalian tissues, although it is overexpressed in a subset of human hepatocellular carcinomas. Its transcription is regulated by b-catenin/TCF and is a target of the Wnt signaling pathway, forming a negative feedback loop that regulates the expression and activity of the Wnt pathway.
Related Pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Western blot analysis of NOTUM in human kidney tissue lysate with NOTUM antibody at (A) 0.5 and (B) 1 ug/ml.
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Immunohistochemistry of NOTUM in human brain tissue with NOTUM antibody at 2.5 ug/ml.
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