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Home Antibody All anti-NOTUM antibodies

Anti-NOTUM Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306819
  • Rabbit Polyclonal NOTUM Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC405887) , 20ug Explanation
100ug 325 In Stock
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WB(1)
IHC(1)
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Also for NOTUM (NM_178493)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenNOTUM antibody was raised against a 19 amino acid peptide near the amino terminus of human NOTUM.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1mg/ml
Guaranteed Application *WB, IHC Suggested DilutionsWB: 0.5 - 1 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens notum pectinacetylesterase homolog (Drosophila) (NOTUM)
Alternative Namenotum
Database LinkNP_848588
FunctionIn Drosophila, the notum gene is regulated by the Wingless pathway and encodes a secreted hydrolase that modifies heparan sulfate proteoglycans. The mammalian homolog has been shown to be able to cleave glypicans and can release GPI-anchored proteins from the mammalian cell surface. Like the Drosophilia NOTUM, the mammalian protein can act as a negative regulator of the Wnt signaling pathway. NOTUM is expressed at a low level in most mammalian tissues, although it is overexpressed in a subset of human hepatocellular carcinomas. Its transcription is regulated by b-catenin/TCF and is a target of the Wnt signaling pathway, forming a negative feedback loop that regulates the expression and activity of the Wnt pathway.
Related Pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of NOTUM in human kidney tissue lysate with NOTUM antibody at (A) 0.5 and (B) 1 ug/ml.
IHC Image
Immunohistochemistry of NOTUM in human brain tissue with NOTUM antibody at 2.5 ug/ml.

 

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