Home Antibody All anti-NOTUM antibodies
Also for NOTUM (NM_178493)
|NOTUM antibody was raised against a 19 amino acid peptide near the amino terminus of human NOTUM.|
|Human, Mouse, Rat
||WB: 0.5 - 1 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column
|Homo sapiens notum pectinacetylesterase homolog (Drosophila) (NOTUM)|
Entrez Gene 147111 Human
Entrez Gene 77583 Mouse
Entrez Gene 303743 Rat
|In Drosophila, the notum gene is regulated by the Wingless pathway and encodes a secreted hydrolase that modifies heparan sulfate proteoglycans. The mammalian homolog has been shown to be able to cleave glypicans and can release GPI-anchored proteins from the mammalian cell surface. Like the Drosophilia NOTUM, the mammalian protein can act as a negative regulator of the Wnt signaling pathway. NOTUM is expressed at a low level in most mammalian tissues, although it is overexpressed in a subset of human hepatocellular carcinomas. Its transcription is regulated by b-catenin/TCF and is a target of the Wnt signaling pathway, forming a negative feedback loop that regulates the expression and activity of the Wnt pathway.|
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Western blot analysis of NOTUM in human kidney tissue lysate with NOTUM antibody at (A) 0.5 and (B) 1 ug/ml.
Immunohistochemistry of NOTUM in human brain tissue with NOTUM antibody at 2.5 ug/ml.