Home Antibody All anti-UCMA antibodies
Also for UCMA (NM_145314)
|UCMA antibody was raised against a 16 amino acid peptide near the carboxy terminus of human UCMA.|
||WB: 2.5 - 5 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column
|Homo sapiens upper zone of growth plate and cartilage matrix associated (UCMA)|
|C10orf49; GRP; GRP/UCMA|
Entrez Gene 221044 Human
Entrez Gene 68527 Mouse
|UCMA is a secreted cartilage-specific protein that was discovered in a screen for differentially expressed genes in retinoic acid-treated mouse chondrocytes. It was also identified in a human chondrocyte EST screen for candidate genes of skeletal dysplasias. UCMA expression is thought to parallel that of collagen II with its expression decreasing with maturation chrondrocytes mature. UCMA is processed by a furin-like protease into two fragments, an amino-terminal fragment and a carboxy-terminal fragment (UCMA-C). Application of recombinant UCMA-C to primary osteoblasts, mesenchymal stem cells, and MC3T3-E1 pre-osteoblasts interferes with their osteogenic differentiation, but does not affect expression of chondrocyte-specific genes or chondrocyte proliferation, suggesting that UCMA may be involved in the negative control of osteogenic differentiation of osteochondrogenic precursor cells. At least two isoforms of UCMA are known to exist.|
|Secreted Protein |
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Western blot analysis of UCMA in SW1353 cell lysate with UCMA antibody at (A) 2.5 and (B) 5 µg/ml.