Home Antibody All anti-OCLN antibodies
Also for OCLN (NM_002538)
|OCLN antibody was raised against a 15 amino acid peptide from near the carboxy terminus of human OCLN.|
|Human, Mouse, Rat
||0.5~1.0 mg/ml (Lot Dependent)
||WB: 1 - 2 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column (Protein A or G Sepharose)
|Homo sapiens occludin (OCLN), transcript variant 1|
|Tight junctions act as a semi-permeable barrier to the transport of ions, solutes, and water and are considered to function as a fence that divides apical and basolateral domains of plasma membranes. Tight junctions coordinate a variety of signaling and trafficking molecules regulating cell differentiation, proliferation, and polarity and contain a number of junctional proteins including Occludin, Claudins, junctional adhesion molecules (JAMs), as well as multiple scaffold proteins. Occludin, the first identified component of tight junction strands, is thought function as a signal transmitter in multiple signaling pathways and can associate with multiple kinases and phosphatases such as PI3-kinase and protein phosphatases 1 and 2A. At least two isoforms of OCLN are known to exist.|
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Western blot analysis of OCLN in human liver tissue lysate with OCLN antibody at 1 ug/ml.
Immunohistochemistry of OCLN in human liver tissue with OCLN antibody at 2.5 ug/ml.