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Home Antibody All anti-RSPO1 antibodies

Anti-RSPO1 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306782
  • Rabbit Polyclonal RSPO1 Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC422005) , 20ug
100ug 325 3-7 Days
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WB(1)
IHC(1)
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Also for RSPO1 (NM_001038633)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenRSPO1 antibody was raised against a 16 amino acid peptide from near the amino terminus of human RSPO1.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1 - 2 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens R-spondin 1 (RSPO1), transcript variant 1
Alternative NameCRISTIN3; RSPO
Database LinkNP_001033722
FunctionRSPO1 is a member of a family of secreted growth factors that can operate through the canonical Wnt signaling pathway by stabilizing the intracellular b-catenin, thereby regulating functions mediated by b-catenin such as cell fate decisions and embryonic patterning. RSPO1 was recently identified through linkage analysis to be involved in sex determination and mammalian ovarian development. RSPO1 is thought to regulate cellular responsiveness to Wnt ligands by modulating the cell-surface expression of the Wnt co-receptor LRP6 by interfering with the DKK/Kremen-mediated internalization of LRP6 through an interaction with Kremen, resulting in increased LRP6 cell-surface levels. At least two isoforms of RSPO1 are known to exist. RSPO1 antibody will not cross-react with RSPO family members.
Related Pathway

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WB Image
Western blot analysis of RSPO1 in rat spleen tissue lysate with RSPO1 antibody at (A) 1 and (B) 2 ug/ml.
IHC Image
Immunohistochemistry of RSPO1 in human spleen tissue with RSPO1 antibody at 2.5 ug/ml.

 

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