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Home Antibody All anti-PDCD5 antibodies

Anti-PDCD5 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306725
  • Rabbit Polyclonal PDCD5 Antibody
  • FREE positive control: HEK293T cell transient overexpression lysate (LC417805) , 20ug
100ug $325 3-7 Days
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WB(1)
IF(1)
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Also for PDCD5 (NM_004708)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenPDCD5 antibody was raised against a 13 amino acid peptide from near the amino terminus of human PDCD5.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB, IF Suggested DilutionsELISA, WB: 2.5 ug/ml, ICC: 5 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens programmed cell death 5 (PDCD5)
Alternative NameTFAR19
Database LinkNP_004699
FunctionProgrammed cell death 5 (PDCD5), a human apoptosis-related protein, is thought to play an early and universal role in apoptosis. PDCD5 is widely expressed and is upregulated in cells undergoing apoptosis, where it translocates rapidly from the cytoplasm to the nucleus. PDCD5 has a compact core structure of low flexibility with two mobile alpha-helices at N-terminal and a flexible unstructured C-terminal region. The charged residues are crucial for the ability of apoptosis-promoting and cell translocation of the protein. PDCD5 can facilitate apoptosis and enhance TAJ/TROY-induced paraptosis-like cell death. PDCD5 may play a dual role in the Tip60 pathway. It interacts with Tip60 and functions as a Tip60 co-activator to promote apoptosis (5). The nucleotide polymorphisms in the 5'-upstream region of PDCD5 affect promoter activity and the susceptibility of a Chinese population to develop chronic myelogenous leukemia and may represent a novel tumor suppressor gene influencing lung cancer.
Related Pathway

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WB Image
Western blot analysis of PDCD5 in Jurkat cell lysate with PDCD5 antibody at 2.5 ug/mL.
IF Image
Immunocytochemistry of PDCD5 in Jurkat cells with PDCD5 antibody at 5 ug/mL.

 

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