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Home Antibody All anti-TTBK1 antibodies

Anti-TTBK1 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306722
  • Rabbit Polyclonal TTBK1 Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC410065) , 20ug Explanation
100ug 325 3-7 Days
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WB(1)
IHC(1)
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Also for TTBK1 (NM_032538)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenTTBK1 antibody was raised against a 16 amino acid peptide near the carboxy terminus of human TTBK1.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse Concentration1ug/ul
Guaranteed Application *WB, IHC Suggested DilutionsELISA, WB: 1 ug/ml, IHC: 2.5 ug/ml, IF: 20 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens tau tubulin kinase 1 (TTBK1)
Alternative NameBDTK
Database LinkNP_115927
Entrez Gene 84630 Human
Entrez Gene 106763 Mouse
FunctionTau tubulin kinase (TTBK1) belongs to the casein kinase 1 superfamily and is involved in the phosphorylation of specific serine/threonine residues in paired helical filaments of the tau protein. It is specifically expressed in the brain and induces tau aggregation in human neuronal cells in a dose-dependent manner. TTBK1 levels have been found to be upregulated in the brains of Alzheimer’s disease (AD) patients, and mice expressing human TTBK1 protein showed significant age-dependent memory impairment. These mice displayed increased levels of the CDK5 activators p25 and p35, and reduced levels of the NMDA receptor types 2B and 2D, suggesting that TTBK1 may play a role in memory dysfunction in AD patients. Multiple isoforms of TTBK1 are known to exist. This antibody is predicted to not cross-react with TTBK2.
Related PathwayProtein KinaseDruggable Genome

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of TTBK1 in Jurkat lysate with TTBK1 antibody at 1 ug/mL.
IHC Image
Immunohistochemistry of TTBK1 in mouse brain tissue with TTBK1 antibody at 2.5 ug/mL.

 

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