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Home Antibody All anti-EBI3 antibodies

Anti-EBI3 Antibody


Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA306705 Rabbit Polyclonal EBI3 Antibody 100ug $325 3-7 Days
LC417095 EBI3 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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OriGene Data

ImmunogenEBI3 antibody was raised against a 16 amino acid peptide from near the center of human EBI3.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB, IHC Suggested DilutionsELISA, WB: 2 ug/ml, IHC: 2.5 ug/ml, IF: 20 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens Epstein-Barr virus induced 3 (EBI3)
Alternative NameIL-27B; IL27B
Database LinkNP_005746
Entrez Gene 10148 Human
Entrez Gene 50498 Mouse
Entrez Gene 680609 Rat
FunctionEBI3 is a subunit in two distinct heterodimeric cytokines: interleukin-27 (IL-27) and IL-35 (1-3). Like interleukin-23 (IL-23), IL-27 is a recently discovered member of the IL-6/IL-12 family of proinflammatory and immunoregulatory cytokines. It exists as a heterodimer composed of the p40-related protein EBI3 and an IL-12 p35-related protein termed p28. IL-27 is produced after activation by antigen-presenting cells and induces proliferation of naïve but not memory CD4+ T-cells. It acts by binding to its receptor WSX-1 (also known as TCCR) and gp130 which results in the activation of a Jak/STAT signaling cascade, suggesting the IL-27 is involved in the regulation of immune processes. It has been suggested that IL-27 can also be used as a therapeutic agent against cancer as it can also induce tumor-specific anti-tumor activity mediated through CD8+ T-cells, IFN-g, and T-bet. IL-35 is composed of EBI3 and the p35 subunit of IL-12 and has been reported to have therapeutic effects against collagen-induced arthritis by expanding the population of regulatory T cells and suppressing Th17 cells. At least two isoform of EBI3 are known to exist.
Related PathwaySecreted ProteinDruggable Genome

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Western blot analysis of EBI3 in rat spleen tissue lysate with EBI3 antibody at 2 ug/mL.
Immunohistochemistry of EBI3 in human spleen tissue with EBI3 antibody at 2.5 ug/mL.


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