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Home Antibody All anti-JPH3 antibodies

Anti-JPH3 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306683
  • Rabbit Polyclonal JPH3 Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC402798) , 20ug
100ug 325 3-7 Days
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WB(1)
IHC(1)

OriGene Data

ImmunogenJPH3 antibody was raised against a 18 amino acid peptide near the carboxy terminus of human JPH3.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1 - 2 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens junctophilin 3 (JPH3), transcript variant 1
Alternative NameCAGL237; HDL2; JP-3; JP3; TNRC22
Database LinkNP_065706
FunctionJunctional complexes between the plasma membrane (PM) and endoplasmic/sarcoplasmic reticulum (ER/SR) are a common feature of all excitable cell types and mediate cross talk between cell surface and intracellular ion channels. Junctophilins (JPs) are important components of the junctional complexes. JPs are composed of a carboxy-terminal hydrophobic segment spanning the ER/SR membrane and a remaining cytoplasmic domain that shows specific affinity for the PM. Four JPs have been identified as tissue-specific subtypes derived from different genes: JPH1 is expressed in skeletal muscle, JPH2 is detected throughout all muscle cell types, and JPH3 and JPH4 are predominantly expressed in the brain. In the CNS, both JPH3 and JPH4 are expressed throughout neural sites and contribute to the subsurface cistern formation in neurons. Mice lacking both JPH3 and JPH4 subtypes exhibit serious symptoms such as impaired learning and memory and are accompanied by abnormal nervous functions. A repeat expansion in JPH3 is associated with Huntington disease-like 2. At least two isoforms of JPH3 are known to exist.
Related Pathway

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WB Image
Western blot analysis of JPH3 in Daudi cell lysate with JPH3 antibody at 1 ug/ml in (A) the absence and (B) the presence of blocking peptide.
IHC Image
Immunohistochemistry of JPH3 in human brain tissue with JPH3 antibody at 2.5 ug/ml.

 

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