Home Antibody All anti-MARCH8 antibodies
Also for MARCH8 (NM_001002265)
|MARCH8 antibody was raised against a 17 amino acid peptide from near the carboxy terminus of human MARCH8.|
|Human, Mouse, Rat
||WB: 0.5 - 1 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column
|Homo sapiens membrane-associated ring finger (C3HC4) 8, E3 ubiquitin protein ligase (MARCH8), transcript variant 1|
|c-MIR; MARCH-VIII; MIR; RNF178|
Entrez Gene 220972 Human
Entrez Gene 71779 Mouse
Entrez Gene 312656 Rat
|MARCH8 (c-MIR) is a novel E3 ubiquitin ligase designated as the modulator of immune recognition (MIR) family, whose catalytic domain is a variant RING domain (RING-CH domain). MARCH8 was found as a functional and structural homolog of KSHV MIR1 and MIR2. MARCH8 targets B7-2 to lysosomal degradation and down-regulates the B7-2 surface expression through ubiquitination of its cytoplasmic tail. Furthermore, MARCH8 has been shown to down-regulate the expression of transferrin receptor and Fas, an important molecule for the induction of apoptosis. MARCH8 is the first example of an E3 ubiquitin ligase that is capable of inhibiting MHC II expression. Recent findings suggest that MARCH8 may regulate immune responses by promoting ubiquitination of MHC-II and CD86, leading to their subsequent endocytosis and lysosomal degradation.|
|TransmembraneDruggable Genome |
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Western blot analysis of MARCH8 in HeLa cell lysate with MARCH8 antibody at (A) 0.5 ug/ml and (B) 1 ug/ml.
Immunocytochemistry of MARCH8 in HeLa cells with MARCH8 antibody at 2.5 ug/ml.