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Home Antibody All anti-MARCH8 antibodies

Anti-MARCH8 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306677
  • Rabbit Polyclonal MARCH8 Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC424197) , 20ug
100ug 325 3-7 Days
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WB(1)
IHC(1)
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Also for MARCH8 (NM_001002265)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenMARCH8 antibody was raised against a 17 amino acid peptide from near the carboxy terminus of human MARCH8.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB, IHC Suggested DilutionsWB: 0.5 - 1 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens membrane-associated ring finger (C3HC4) 8, E3 ubiquitin protein ligase (MARCH8), transcript variant 1
Alternative Namec-MIR; MARCH-VIII; MIR; RNF178
Database LinkNP_001002265
FunctionMARCH8 (c-MIR) is a novel E3 ubiquitin ligase designated as the modulator of immune recognition (MIR) family, whose catalytic domain is a variant RING domain (RING-CH domain). MARCH8 was found as a functional and structural homolog of KSHV MIR1 and MIR2. MARCH8 targets B7-2 to lysosomal degradation and down-regulates the B7-2 surface expression through ubiquitination of its cytoplasmic tail. Furthermore, MARCH8 has been shown to down-regulate the expression of transferrin receptor and Fas, an important molecule for the induction of apoptosis. MARCH8 is the first example of an E3 ubiquitin ligase that is capable of inhibiting MHC II expression. Recent findings suggest that MARCH8 may regulate immune responses by promoting ubiquitination of MHC-II and CD86, leading to their subsequent endocytosis and lysosomal degradation.
Related Pathway

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WB Image
Western blot analysis of MARCH8 in HeLa cell lysate with MARCH8 antibody at (A) 0.5 ug/ml and (B) 1 ug/ml.
IHC Image
Immunocytochemistry of MARCH8 in HeLa cells with MARCH8 antibody at 2.5 ug/ml.

 

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