Home Antibody All anti-DISP2 antibodies
Also for DISP2 (NM_033510)
|Disp2 antibody was raised against a 19 amino acid peptide from near the carboxy terminus of human Disp2.|
|Human, Mouse, Rat
||Lot dependent; please refer to CoA along with shipment
||WB: 1 - 2 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column
|Homo sapiens dispatched homolog 2 (Drosophila) (DISP2)|
Entrez Gene 85455 Human
Entrez Gene 214240 Mouse
Entrez Gene 311324 Rat
|Disp2 is the second of three known homologs of the D. melanogaster protein Dispatched. It is a multi-transmembrane protein containing two PTCH/DISP domains and is thought to be involved in the release of lipid-anchored Hedgehog from producing cells. Hedgehog is a major player in signaling pathways during embryogenesis, tissue regeneration, and carcinogenesis and the Disp proteins have been implicated in these pathways. Recently, it has been shown that Disp2 is translationally regulated by the microRNA miR-214 in zebrafish. Expression of this miRNA decreased Disp2 promoter activity in vitro and its overexpression in zebrafish resulted in a phenotype identical to that observed by Disp2 mutants. At least two isoforms of Disp2 are known to exist. This Disp2 antibody is predicted to not cross-react with Disp1 or Disp3.|
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Western blot analysis of Disp2 in rat brain tissue lysate with Disp2 antibody at (A) 1 and (B) 2 µg/ml.