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Home Antibody All anti-SPRED1 antibodies

Anti-SPRED1 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306662
  • Rabbit Polyclonal Spred1 Antibody
  • FREE positive control: HEK293T cell transient overexpression lysate (LC407400) , 20ug
100ug 325 3-7 Days
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WB(1)
IHC(1)
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Also for SPRED1 (NM_152594)
cDNA Clone shRNA/siRNA Lysate Protein Request Antibody

OriGene Data

ImmunogenSpred1 antibody was raised against a 14 amino acid peptide near the center of the human Spred1.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1 - 2 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens sprouty-related, EVH1 domain containing 1 (SPRED1)
Alternative NamehSpred1; NFLS; spred-1
Database LinkNP_689807
FunctionThe Ras-MAP kinase pathway is essential for the differentiation of neuronal cells and myocytes; it is inhibited by Spred1, a member of the Sprouty family of proteins. Spred1 acts by suppressing the phosphorylation and activation of Raf. The Spred proteins have also been implicated in the negative feedback regulation of FGF signaling in embryogenesis and angiogenesis. Further studies have shown that expression levels of Spred1 and Spred2 proteins are inversely correlated with the incidence of tumor invasion and metastasis in human hepatocellular carcinoma (HHC), suggesting that these proteins could be useful as prognostic factors and therapeutic targets in HCC. Defects in this gene are a cause of neurofibromatosis type 1-like syndrome (NFLS). This Spred1 antibody is predicted to have no cross-reactivity to Spred2 or Spred3.
Related Pathway
Jak-STAT signaling pathway

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WB Image
Western blot analysis of Spred1 in human brain tissue lysate with Spred1 antibody at (A) 1 and (B) 2 ug/ml.
IHC Image
Immunohistochemistry of Spred1 in human brain tissue with Spred1 antibody at 2.5 ug/ml.

 

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