Home Antibody All anti-BICD1 antibodies
Also for BICD1 (NM_001003398)
|BICD1 antibody was raised against a 15 amino acid peptide from near the carboxy terminus of human BICD1.|
|Human, Mouse, Rat
||ELISA, WB: 1 ug/ml, ICC: 2.5 ug/ml, IF: 10 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column (Protein A or G Sepharose)
|Homo sapiens bicaudal D homolog 1 (Drosophila) (BICD1), transcript variant 2|
|BICD1 was initially identified as the human homolog to Drosophila Bicaudal-D protein that forms part of the cytoskeleton and mediates the correct sorting of mRNAs for oocyte- and axis-determining factors during oogenesis. BICD1 can bind to dynein-dynactin and co-localizes with Rab6A on the trans-Golgi network and cytoplasmic vesicles, suggesting BICD1 regulates COPI-independent Golgi-ER transport. BICD1 will also interact with Rab6B, a Rab6 isoform that is expressed primarily in brain. Live cell imaging showed bi-directional movement of Rab6B structures in SK-N-SH neurites, indicating that BICD1 is involved in the Rab6B regulation of retrograde cargo transport in neuronal cells. At least two isoforms of BICD1 are known to exist; this antibody will only recognize the larger isoform.|
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Western blot analysis of BICD1 in Daudi cell lysate with BICD1 antibody at 1 ug/mL in (A) the absence and (B) the presence of blocking peptide.
Immunocytochemistry of BICD1 in Daudi cells with BICD1 antibody at 2.5 ug/mL.