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Home Antibody All anti-BICD1 antibodies

Anti-BICD1 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306601
  • Rabbit Polyclonal BICD1 Antibody
100ug 325 3-7 Days
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WB(1)
IF(1)

OriGene Data

ImmunogenBICD1 antibody was raised against a 15 amino acid peptide from near the carboxy terminus of human BICD1.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB, IF Suggested DilutionsELISA, WB: 1 ug/ml, ICC: 2.5 ug/ml, IF: 10 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens bicaudal D homolog 1 (Drosophila) (BICD1), transcript variant 2
Alternative NameBICD
Database LinkNP_001003398
Entrez Gene 636 Human
Entrez Gene 12121 Mouse
Entrez Gene 362466 Rat
FunctionBICD1 was initially identified as the human homolog to Drosophila Bicaudal-D protein that forms part of the cytoskeleton and mediates the correct sorting of mRNAs for oocyte- and axis-determining factors during oogenesis. BICD1 can bind to dynein-dynactin and co-localizes with Rab6A on the trans-Golgi network and cytoplasmic vesicles, suggesting BICD1 regulates COPI-independent Golgi-ER transport. BICD1 will also interact with Rab6B, a Rab6 isoform that is expressed primarily in brain. Live cell imaging showed bi-directional movement of Rab6B structures in SK-N-SH neurites, indicating that BICD1 is involved in the Rab6B regulation of retrograde cargo transport in neuronal cells. At least two isoforms of BICD1 are known to exist; this antibody will only recognize the larger isoform.
Related Pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of BICD1 in Daudi cell lysate with BICD1 antibody at 1 ug/mL in (A) the absence and (B) the presence of blocking peptide.
IF Image
Immunocytochemistry of BICD1 in Daudi cells with BICD1 antibody at 2.5 ug/mL.

 

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